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MLN120B Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764553

MBS5764553 is an inhibitor targeting MLN120B. MLN120B is a selective and ATP competitive IKKbeta inhibitor (IC50: 60nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MLN120B, Inhibitor
Full Product Name
MLN120B
Product Gene Name
MLN120B, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
366.8
Solubility
DMSO: 30mg/mL (81.78mM)
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H15ClN4O2
SMILES
Cc(nccc1)c1C(Nc1c2[nH]c(cncc3)c3c2cc(Cl)c1OC)=O
CAS Number
783348-36-7
Cell Research
Multiple myeloma cells are cultured with MLN120B, harvested, washed, and lysed using lysis buffer [50mM Tris-HCl (pH 7.4), 150mM NaCl, 1% NP40, 5mM EDTA, 5mM NaF, 2mM Na3VO4, 1mM phenylmethylsulfonyl fluoride, 5ug/mL leupeptin, 5ug/mL aprotinin]. Whole-cell lysates are subjected to Western blotting using phosphorylated IkappaBalpha, IkappaBalpha, phosphorylated p65 NF-kappaB, and p65 NF-kappaB antibodies [1].
In Vitro
MLN120B (50mg/kg, p.o.) inhibits human multiple myeloma cell growth in vivo [1]. MLN120B (12mg/kg twice daily, p.o.) inhibits paw swelling in a dose-dependent manner and offers significant protection against arthritis-induced weight loss as well as cartilage and bone erosion [2].

Product Categories/Family for MLN120B, inhibitor

NF-kappab; IkappaB/IKK

Product References and Citations for MLN120B, inhibitor

Hideshima T, et all. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin Cancer Res. 2006 Oct 1;12(19):5887-94.
Hideshima T, et all. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin Cancer Res. 2006 Oct 1;12(19):5887-94.
Schopf L, et al. IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. Arthritis Rheum. 2006 Oct;54(10):3163-73.
Schopf L, et al. IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. Arthritis Rheum. 2006 Oct;54(10):3163-73.
Ansaldi D, et al. Imaging pulmonary NF-kappaB activation and therapeutic effects of MLN120B and TDZD-8. PLoS One. 2011;6(9):e25093.
Ansaldi D, et al. Imaging pulmonary NF-kappaB activation and therapeutic effects of MLN120B and TDZD-8. PLoS One. 2011;6(9):e25093.

Other Notes

Small volumes of MLN120B, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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