Glaucocalyxin B Inhibitor

Name: Glaucocalyxin B Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764556
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764556

Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86uM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glaucocalyxin B, Inhibitor

Full Product Name

Glaucocalyxin B

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

374.47

Solubility

DMSO: Soluble
(<1mg/ refers to the product slightly soluble or insoluble)

Formula

C22H27O5

SMILES

CC1(C)C(CC[C@@]2(C)[C@@]3([H])[C@@]4(C(C([C@](CC3)[C@]4OC(C)=O)=C)=O)[C@](O)C[C@]12[H])=O

CAS Number

80508-81-2

Cell Research

The microglia cell viability is assessed by MTT assay. Cells are seeded in 96-well plates at the density of 5 x 10^4cells/well. The cell culture supernatant is discarded after treatment with various agents, and then 30uL of MTT (0.5mg/mL) solution is added into each well. After incubation for 4 hours at 37 degree C, 100uL of DMSO is added into each well to dissolve the formazan dye, and then the absorbance of solubilized formazan is measured by microplate reader [3].

Product Categories/Family for Glaucocalyxin B, inhibitor

Autophagy; Autophagy

Product References and Citations for Glaucocalyxin B, inhibitor

Yang WH, et al. Glaucocalyxin A and B-induced cell death is related to GSH perturbation in human leukemia HL-60 cells. Anticancer Agents Med Chem. 2013 Oct;13(8):1280-90.
Yang WH, et al. Glaucocalyxin A and B-induced cell death is related to GSH perturbation in human leukemia HL-60 cells. Anticancer Agents Med Chem. 2013 Oct;13(8):1280-90.
Pan Y, et al. Glaucocalyxin B induces apoptosis and autophagy in human cervical cancer cells. Mol Med Rep. 2016 Aug;14(2):1751-5.
Pan Y, et al. Glaucocalyxin B induces apoptosis and autophagy in human cervical cancer cells. Mol Med Rep. 2016 Aug;14(2):1751-5.
Gan P, et al. Anti-inflammatory effects of glaucocalyxin B in microglia cells. J Pharmacol Sci. 2015 May;128(1):35-46.
Gan P, et al. Anti-inflammatory effects of glaucocalyxin B in microglia cells. J Pharmacol Sci. 2015 May;128(1):35-46.

Other Notes

Small volumes of Glaucocalyxin B, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Glaucocalyxin B purchase

MBS5764556 is an inhibitor targeting Glaucocalyxin B.