NVP-BAG956 Inhibitor

Name: NVP-BAG956 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764560
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764560

NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444nM for PI3Kdelta/PI3Kalpha/PI3Kgamma/PI3Kbeta). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NVP-BAG956, Inhibitor

Full Product Name

NVP-BAG956

Product Gene Name

NVP-BAG956, inhibitor

Product Synonym Names

BAG956

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

427.5

Solubility

DMSO: Soluble
(<1mg/ refers to the product slightly soluble or insoluble)

Formula

C28H21N5

SMILES

CC(C)(c(cc1)ccc1-n1c(c2cc(C#Cc3cnccc3)ccc2nc2)c2nc1C)C#N

CAS Number

853910-02-8

Cell Research

One day after plating (7x10^3 cells/cm2), melanoma cells (A2058, B16F1, B16F10, C32, HBL, Malme, Malme3M, NA8, SKMel2, SKMel23, A375, Hs294T, WM35, and 1205lu cells) are exposed to LY294002 (25uM), Wortmannin (500nM), NVP-BAG956 (1uM), NVP-BBD130 (1uM), NVP-BEZ235 (1uM), and ZSTK474 (1uM), and Rapamycin (100nM). Compound concentrations are set 2 log units above the IC50 in vitro to ensure full PI3K inhibition, except for the uM inhibitor LY294002. Cells are trypsinized and counted, and the volume is quantified using a Casy Counter and Analyser. To determine the nuclear volume, cells are resuspended in CASYton containing 0.5% Triton X-100, followed by repetitive pipetting (8x), before volume measurements.

Product Categories/Family for NVP-BAG956, inhibitor

PI3K/Akt/mTOR signaling; PI3K

Product References and Citations for NVP-BAG956, inhibitor

Marone R, et al. Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors. Mol Cancer Res. 2009 Apr;7(4):601-13.

Other Notes

Small volumes of NVP-BAG956, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NVP-BAG956 purchase

MBS5764560 is an inhibitor targeting NVP-BAG956.