EMD534085 Inhibitor

Name: EMD534085 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764561
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764561

EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EMD534085, Inhibitor

Full Product Name

EMD534085

Product Gene Name

EMD534085, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

476.53

Solubility

DMSO: 25mg/mL (52.46mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C25H31F3N4O2

SMILES

CN(C)CCNC(NC[C@@H](CC[C@H]12)O[C@@H]1c(cc(C(F)(F)F)cc1)c1N[C@H]2c1ccccc1)=O

CAS Number

858668-07-2

Cell Research

Epithelial cell lines HeLa and MCF7 are synchronized in G2-phase using RO-3306. Cells are treated with 10uM RO-3306 for 16 hrs, and then are ished and released to either warm growth medium or medium supplemented with 500nM EMD534085 [2].

In Vitro

In a low dose PK of EMD 534085 in mice, the clearance is 1.8L/h/kg on average, the volume of distribution is 7.4L/kg and the half-life around 2.5 hours. The bioavailability in high dose experiments (>10mg/kg) is always above 50% in mice. Intraperitoneal administration of EMD 534085 enables significant systemic exposure in mice leading to a significant tumor growth reduction without toxic side effects [1].

Product Categories/Family for EMD534085, inhibitor

Cytoskeletal Signaling; Kinesin

Product References and Citations for EMD534085, inhibitor

Schiemann K, et al. The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5.
Schiemann K, et al. The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5.
Tang Y, et al. Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. Cancer Lett. 2011 Nov 1;310(1):15-24.
Tang Y, et al. Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. Cancer Lett. 2011 Nov 1;310(1):15-24.

Other Notes

Small volumes of EMD534085, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EMD534085 purchase

MBS5764561 is an inhibitor targeting EMD534085.