Tandospirone Inhibitor

Name: Tandospirone Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5764562
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764562

Tandospirone (SM-3997) is a selective partial agonist of 5-HT1A receptor (Ki: 27nM) that displays selectivity over SR-2, SR-1C, alpha1, alpha2, D1 and D2 receptors (Kis: 1300-41000nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tandospirone, Inhibitor

Full Product Name

Tandospirone

Product Synonym Names

SM-3997

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

383.49

Solubility

DMSO: 30mg/mL
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H29N5O2

SMILES

O=C([C@H]1[C@@H]2[C@H]3C[C@@H]1CC3)N(CCCCN(CC1)CCN1c1ncccn1)C2=O

CAS Number

87760-53-0

In Vitro

Chronic treatment with tandospirone, at 0.2 and 1.0mg/kg/day, but not 2.0mg/kg/day, attenuated footshock stress-induced eLAC elevation in the mPFC [3]. Rats were acutely administered tandospirone (0, 0.1, and 1mg/kg, i.p.). Tandospirone decreased the number of premature responses, an index of impulsive action, in a dose-dependent manner [4].

Product Categories/Family for Tandospirone, inhibitor

GPCR/G Protein; 5-HT Receptor; Neuroscience

Product References and Citations for Tandospirone, inhibitor

Hamik A, et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol Psychiatry. 1990 Jul 15;28(2):99-109.
Hamik A, et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol Psychiatry. 1990 Jul 15;28(2):99-109.
Shimizu H, et al. Characterization of the putative anxiolytic SM-3997 recognition sites in rat brain. Life Sci. 1988;42(24):2419-27.
Shimizu H, et al. Characterization of the putative anxiolytic SM-3997 recognition sites in rat brain. Life Sci. 1988;42(24):2419-27.
Uehara T, et al. Chronic treatment,with tandospirone, a 5-HT1A receptor partial agonist, suppresses footshock stress-induced lactate production in the prefrontal cortex of rats. Pharmacol Biochem Behav. 2013 Nov 15;113:1-6.
Uehara T, et al. Chronic treatment,with tandospirone, a 5-HT1A receptor partial agonist, suppresses footshock stress-induced lactate production in the prefrontal cortex of rats. Pharmacol Biochem Behav. 2013 Nov 15;113:1-6.
Ohmura Y, et al. Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor. J Pharmacol Sci. 2013;122(2):84-92.
Ohmura Y, et al. Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor. J Pharmacol Sci. 2013;122(2):84-92.

Other Notes

Small volumes of Tandospirone, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tandospirone purchase

MBS5764562 is an inhibitor targeting Tandospirone.