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BIBF1202 Inhibitor – BIBF 1202

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5764567

MBS5764567 is an inhibitor targeting BIBF1202. Also known as BIBF 1202. BIBF 1202 is a VEGFR2 kinase inhibitor (IC50: 62nM). More details

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Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BIBF 1202 (BIBF1202), Inhibitor
Full Product Name
BIBF 1202
Product Gene Name
BIBF1202, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
525.6
Solubility
DMSO: 40mg/mL (76.1mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C30H31N5O4
SMILES
CN(C(CN1CCN(C)CC1)=O)C(C=C2)=CC=C2N/C(C3=CC=CC=C3)=C4C(NC5=C\4C=CC(C(O)=O)=C5)=O
CAS Number
894783-71-2
In Vitro
The major metabolic pathway for BIBF 1120 is methyl ester cleavage to BIBF 1202. Then, the free carboxyl group of BIBF 1202 is glucuronidated to 1-O-acyl glucuronide [2].

Product Categories/Family for BIBF1202, inhibitor

Angiogenesis; VEGFR; Tyrosine Kinase/Adaptors

Product References and Citations for BIBF1202, inhibitor

Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumorefficacy. Cancer Res. 2008 Jun 15;68(12):4774-82.
Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumorefficacy. Cancer Res. 2008 Jun 15;68(12):4774-82.
Stopfer P, et al. Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers. Xenobiotica. 2011 Apr;41(4):297-311.
Stopfer P, et al. Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers. Xenobiotica. 2011 Apr;41(4):297-311.

Other Notes

Small volumes of BIBF1202, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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