Mouse Anti-FCNB Monoclonal Antibody – Cat# MBS584022

Ficolin-2 (FCNB) Antibody – Mouse Monoclonal

Name: FCNB Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS584022
Price: 955 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS584022

Product Description: The monoclonal antibody GN4 recognizes human Ficolin-2, also known as L-ficolin. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the… More details

$955 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ficolin-2 (Fcnb), Monoclonal Antibody

Full Product Name

Ficolin-2, Human, mAb GN4

Product Gene Name

anti-Fcnb antibody

Clonality

Monoclonal

Isotype

Mouse IgG1

Host

Mouse

Species Reactivity

Human

Form/Format

1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine Serum albumin.
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)

Preparation and Storage

Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.

Molecular Weight

33,984 Da

Applications Tested/Suitable for anti-Fcnb antibody

Immunoassay (IA), Immunoprecipitation (IP)

Product References and Citations for anti-Fcnb antibody

1. Matsushita, M et al; Activation of the lectin complement pathway by ficolins. Int Immunopharmacol 2001, 1: 359 2. Matsushita, M et al; Activation of the lectin complement pathway by H-ficolin (Hakata antigen). J of Immunol 2002, 168: 3502
3. Matsushita, M et al; The role of ficolins in innate immunity. Immunobiol 2002, 205: 490

Other Notes

Small volumes of anti-Fcnb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Fcnb purchase

MBS584022 is an antibody targeting Fcnb. Also known as Ficolin-2, Human, mAb GN4. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Fcnb. It may not necessarily be applicable to this product.

NCBI GI #

77404440

NCBI GeneID

14134

NCBI Accession #

NP_034320.1

UniProt Secondary Accession #

Q3KNL6

UniProt Related Accession #

O70497

GenBank Nucleotide #

NM_010190.1

NCBI Official Full Name

ficolin-2

NCBI Official Synonym Full Names

ficolin B

NCBI Official Symbol

Fcnb

NCBI Official Synonym Symbols

Fcn2

UniProt Protein Name

Ficolin-2

UniProt Synonym Protein Names

Collagen/fibrinogen domain-containing protein 2; Ficolin-B; Ficolin-beta; L-ficolin

Protein Family

Ficolin

UniProt Gene Name

Fcn2

UniProt Synonym Gene Names

Fcnb

UniProt Entry Name

FCN2_MOUSE

NCBI Protein Information

ficolin-2; L-ficolin; ficolin-B; ficolin-beta; collagen/fibrinogen domain-containing protein 2

UniProt Comments for Fcnb

FCN2: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: collagen; extrinsic to external side of plasma membrane; extracellular region

Molecular Function: G-protein-coupled receptor binding; carbohydrate binding; sialic acid binding; pattern recognition receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of virion penetration into host cell; immune system process; cell surface pattern recognition receptor signaling pathway; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell

Research Articles on Fcnb

1. Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Fcnb antibody

Products by Pathway	Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Creation Of C4 And C2 Activators Pathway antibodies	Creation Of C4 And C2 Activators Pathway Diagram
Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway antibodies	Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Lectin Pathway Of Complement Activation antibodies	Lectin Pathway Of Complement Activation Diagram

Diseases associated with anti-Fcnb antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>2 publications with Fcnb and Necrosis
Lung Diseases Antibodies	>1 publications with Fcnb and Lung Diseases
Autoimmune Diseases Antibodies	>1 publications with Fcnb and Autoimmune Diseases
Immune System Diseases Antibodies	>1 publications with Fcnb and Immune System Diseases