CR1/CR2 Antibody – Rat Monoclonal

Product Description: The monoclonal antibody 7E9 recognizes mouse complement receptors type 1 (CR1) and 2 (CR2). CR1 and CR2 are cell surface glycoproteins that are capable of binding to activation fragments of the third and/or fourth complement components (C3 and/or C4). They play a role in the clearance of immune-complexes, phagocytosis, complement regulation, and immunoregulation. Mouse CR1 (MCR1, 190 kD) is found on the surface of B-lymphocytes, follicular dendritic cells and at lower levels on peritoneal macrophages and activated granulocytes. MRC1 has binding activity for C3b and serves as a cofactor for factor I-mediated cleavage of C3b. Mouse CR2 (MCR2, 150 kD) is a type I transmembrane glycoprotein that binds complement fragments (C3d(g), iC3b) and interferon (IFN)-alpha. MCR2 is expressed on B-lymphocytes and probably on follicular dendritic cells. On human B lymphocytes it acts as the Epstein-Barr virus (EBV) receptor. MCR2 mediates the formation of rosettes between B-lymphocytes and E-bearing Crd. MCR1 and MRC2 are very closely related. They are both products of a single gene, Cr2, formed by alternative splicing of mRNA. MCR2 corresponds to the carboxy-terminal portion of MCR1. This is in contrast with human CR1 (CD35) and CR2. The monoclonal antibody 7E9 does not inhibit rosette formation between 2PK3 cells and Crd-coated SRBC indicator cells.

1. Kinoshita, T et al; Monoclonal antibodies to mouse complement receptor type 1 (CR1): their use in a distribution study showing that mouse erthrocytes and platelets are CR1-negative. J Immunol 1988, 140: 3066 2. Kinoshita, T. et al; Characterization of murine complement receptor type 2 (CR2) and its immunological cross-reactivity with type 1 receptor (CR1). Inter Immunol 1990, 2: 651
3. Pramoonjago, P. et al; Ligand specificities of mouse complement receptors type 1 (CR1) and type 2 (CR2) purified from spleen cells. Int Immunol 1993, 5: 337
4. Hoefer, M et al; Modulation of murine complement receptor type 2 (CR2/CD21) ectodomain shedding by its cytoplasmic domain. Mol Immunol 2008, 45: 2127

Small volumes of anti-CR1/CR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS584116 is an antibody targeting CR1/CR2. Also known as CR1/CR2, Mouse, mAb 7E9. Reactive in Mouse. Host: Rat.