Rat Anti-MBL-C Monoclonal Antibody – Cat# MBS584209

MBL-C Antibody – Rat Monoclonal

Name: MBL-C Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS584209
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS584209

Product Description: Mannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL… More details

$880 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MBL-C, Monoclonal Antibody

Full Product Name

MBL-C, Mouse, mAb 16A8

Product Gene Name

anti-MBL-C antibody

Clonality

Monoclonal

Isotype

Rat IgG2a

Host

Rat

Species Reactivity

Mouse

Form/Format

1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)

Preparation and Storage

Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.

Molecular Weight

25,957 Da

Applications Tested/Suitable for anti-MBL-C antibody

Immunoassay (IA), Western Blot (WB)

Application Notes for anti-MBL-C antibody

Application Notes: The monoclonal antibody 16A8 can be used for immuno assay and Western blotting (non-reduced). The antibody 16A8 is not useful for immunohistology.
Application Use: For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. It is recommended that solutions with a calcium concentration of 1 mM are used (16A8 is a calcium-dependent antibody).

Product References and Citations for anti-MBL-C antibody

1. Liu, H et al; Characterization and Quantification of Mouse Mannan-Binding Lectins (MBL-A and MBL-C) and Study of Acute Phase Responses. Scand J Immunol 2001, 53: 489 2. Sastry, K et al; Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant. J Immunol 1991, 147: 692

Other Notes

Small volumes of anti-MBL-C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MBL-C purchase

MBS584209 is an antibody targeting MBL-C. Also known as MBL-C, Mouse, mAb 16A8. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for MBL-C. It may not necessarily be applicable to this product.

NCBI GI #

6754656

NCBI GeneID

17195

NCBI Accession #

NP_034906.1

UniProt Related Accession #

P41317

GenBank Nucleotide #

NM_010776.1

NCBI Official Full Name

mannose-binding protein C

NCBI Official Synonym Full Names

mannose-binding lectin (protein C) 2

NCBI Official Symbol

Mbl2

NCBI Official Synonym Symbols

MBL; L-MBP; MBL-C; MBP-C

UniProt Protein Name

Mannose-binding protein C

UniProt Synonym Protein Names

Mannan-binding protein; RA-reactive factor P28A subunit; RARF/P28A

UniProt Gene Name

Mbl2

UniProt Synonym Gene Names

MBP-C; RARF/P28A

UniProt Entry Name

MBL2_MOUSE

NCBI Protein Information

mannose-binding protein C; RARF/P28A; mannan-binding protein; mannose binding lectin (C); RA-reactive factor P28A subunit; mannose binding lectin, liver (C)

UniProt Comments for MBL-C

MBL2: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular space; collagen; extracellular region

Molecular Function: mannose binding; protein self-association; protease binding; galactose binding; calcium ion binding; carbohydrate binding; calcium-dependent protein binding; receptor binding

Biological Process: defense response to Gram-positive bacterium; killing by host of symbiont cells; immune system process; positive regulation of phagocytosis; innate immune response; complement activation, lectin pathway; negative regulation of viral reproduction; complement activation, classical pathway

Research Articles on MBL-C

1. ALI in H5N1-infected mice was caused by excessive complement activation, as demonstrated by deposition of C3, C5b-9, and MBL-C in lung tissue, and by up-regulation of MBL-associated serine protease-2 and the complement receptors C3aR and C5aR.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MBL-C antibody

Reference Product	PubMed Publications
Masp2 antibody	>35 publications with MBL-C and Masp2
Masp1 antibody	>7 publications with MBL-C and Masp1
C1qa antibody	>1 publications with MBL-C and C1qa

Pathways associated with anti-MBL-C antibody

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Creation Of C4 And C2 Activators Pathway antibodies	Creation Of C4 And C2 Activators Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Lectin Pathway Of Complement Activation antibodies	Lectin Pathway Of Complement Activation Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram

Diseases associated with anti-MBL-C antibody

Disease Name	Pubmed Publications
Infection Antibodies	>200 publications with MBL-C and Infection
Inflammation Antibodies	>79 publications with MBL-C and Inflammation
Liver Diseases Antibodies	>31 publications with MBL-C and Liver Diseases
Fibrosis Antibodies	>27 publications with MBL-C and Fibrosis
HIV Infections Antibodies	>25 publications with MBL-C and HIV Infections
Hepatitis Antibodies	>20 publications with MBL-C and Hepatitis
Heart Diseases Antibodies	>19 publications with MBL-C and Heart Diseases
Necrosis Antibodies	>18 publications with MBL-C and Necrosis
Disease Models, Animal Antibodies	>13 publications with MBL-C and Disease Models, Animal
Atherosclerosis Antibodies	>12 publications with MBL-C and Atherosclerosis