Lipoteichoic Acid Antibody – Mouse Monoclonal

Product Description: The monoclonal antibody 55 recognizes lipoteichoic acid (LTA). LTA, a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. LTA is anchored via its glycolipids to the membrane and carries a polysaccharide chain extending into the peptidoglycan layer of the cell wall. LTA is released spontaneously into the culture medium during growth of gram-positive bacteria. LTA functions as an immune activator with characteristics very similar to lipopolysaccharide (LPS) from Gram-negative bacteria. LTA binds to CD14 and triggers activation predominantly via Toll-like receptor 2.- Although LTA is internalized and traffics to the Golgi, the cellular activation in response to LTA occurs at the cell surface.

1. Hogg,S et al; Occurrence of lipotechoic acid in oral streptococci. Int. journal of systematic bacteriology 1997, 47:62 2. Langevelde, P et al; Antibiotic-induced release of lipoteichoic acid and peptidoglycan from Staphylococcus aureus: Quantitative measurements and biological reactivities. Antimicrob Agents Chemother 1998, 42: 3073
3. Langevelde, P et al; Antibiotic-induced cell wall fragments of Staphylococcus aureus increase endothelial chemokine secretion and adhesiveness for granulocytes. Antimicrob Agents Chemother 1999, 43: 2984
4. Triantafilou, M et al; Lipoteichoic acid and toll-like receptor 2 internalization and targeting to the golgi are lipid raft-dependent. J Biol Chem 2004, 279: 40882
5. Henneke, P et al; Role of lipoteichoic acid in the phagocyte response to group B Streptococcus. J Immunol 2005, 174: 6449
6. Grundling, A et al. Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus. PNAS 2007, 104:8478
7. Jimenez-Dalmaroni, M et al. Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. Plos One 2009, 4:7411
8. Yajima, A et al. Contribution of phosphoglucosamine mutase to the resistance of Streptococcus gordonii DL1 to polymorphonuclear leukocyte killing. FEMS Microbiol lett 2009, 297: 196
9. Hashimoto, Y et al. Identification of LTA as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes. I.Immunol 2009, 183:7451
10. Hirose, Y et al. Lipoteichoic acids on lactobacillus platarum cell surfaces correlate with induction of interleukin-12p40 production. Microbiol immunol 2010, 54:143

Small volumes of anti-Lipoteichoic Acid antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS584232 is an antibody targeting Lipoteichoic Acid. Also known as Lipoteichoic Acid, mAb 55. Host: Mouse.