Mouse Anti-DCD Monoclonal Antibody – Cat# MBS584244

Dermcidin (DCD) Antibody – Mouse Monoclonal

Name: DCD Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS584244
Price: 620 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS584244

Product Description: The monoclonal antibody G-81 recognizes a fragment of human dermcidin (DCD). The antibiotic peptide dermcidin (110 amino acids) is specifically and constitutively expressed in the sweat glands. DCD is localized to the dark mucous cells of… More details

$620 / 0.2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Dermcidin (DCD), Monoclonal Antibody

Full Product Name

Dermcidin, Human, mAb G-81

Product Gene Name

anti-DCD antibody

Product Synonym Names

AIDD, PIF, DSEP, HCAP, DCD-1

Clonality

Monoclonal

Isotype

Mouse IgM

Host

Mouse

Species Reactivity

Human

Form/Format

1 ml (> 200 ug/ml) culture medium with a low endotoxin level containing 0.02% sodium azide.
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)

Preparation and Storage

Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.

Molecular Weight

8,295 Da

OMIM

606634

Immunogen

Fractioned sweat peptides in complete Freund's adjuvant

Applications Tested/Suitable for anti-DCD antibody

Immunoassay (IA), P, Western Blot (WB)

Application Notes for anti-DCD antibody

Application Use: For immunohistology and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product References and Citations for anti-DCD antibody

1. Sagawa, K et al; Production and characterization of a monoclonal antibody for sweat-specific protein and its application for sweat identification. Int J Legal Med 2003, 117: 90 2. Minami, Y et al; Immunohistochemical staining of cutaneous tumours with G-81, a monoclonal antibody to dermcidin. Br J Dermatol 2004, 151: 165

Other Notes

Small volumes of anti-DCD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DCD purchase

MBS584244 is an antibody targeting DCD. Also known as Dermcidin, Human, mAb G-81. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DCD. It may not necessarily be applicable to this product.

NCBI GI #

16751921

NCBI GeneID

117159

NCBI Accession #

NP_444513.1

UniProt Secondary Accession #

P58461; Q53YJ2; A5JHP2; A5JHP3

UniProt Related Accession #

P81605

GenBank Nucleotide #

NM_053283.3

NCBI Official Full Name

dermcidin isoform 1 preproprotein

NCBI Official Synonym Full Names

dermcidin

NCBI Official Symbol

DCD

NCBI Official Synonym Symbols

PIF; AIDD; DSEP; HCAP; DCD-1

UniProt Protein Name

Dermcidin

UniProt Synonym Protein Names

PreproteolysinCleaved into the following 2 chains:Survival-promoting peptide; DCD-1

Protein Family

Bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase

UniProt Gene Name

DCD

UniProt Synonym Gene Names

AIDD; DSEP

UniProt Entry Name

DCD_HUMAN

NCBI Protein Information

dermcidin; preproteolysin; survival promoting peptide; proteolysis inducing factor; diffusible survival/evasion peptide

NCBI Summary for DCD

This gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

UniProt Comments for DCD

DCD: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; EC 3.4.-.-

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: extracellular region

Molecular Function: peptidase activity

Biological Process: killing of cells of another organism; defense response to bacterium; proteolysis; defense response to fungus

Research Articles on DCD

1. Crystal structure and functional mechanism of a human antimicrobial membrane channel

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DCD antibody

Reference Product	PubMed Publications
CAMP antibody	>2 publications with DCD and CAMP
UBC antibody	>2 publications with DCD and UBC

Diseases associated with anti-DCD antibody

Disease Name	Pubmed Publications
Ischemia Antibodies	>193 publications with DCD and Ischemia
Cardiovascular Diseases Antibodies	>157 publications with DCD and Cardiovascular Diseases
Liver Failure Antibodies	>50 publications with DCD and Liver Failure
Kidney Diseases Antibodies	>43 publications with DCD and Kidney Diseases
Necrosis Antibodies	>40 publications with DCD and Necrosis
Inflammation Antibodies	>25 publications with DCD and Inflammation
Renal Insufficiency Antibodies	>22 publications with DCD and Renal Insufficiency
Memory Disorders Antibodies	>21 publications with DCD and Memory Disorders
Pain Antibodies	>19 publications with DCD and Pain
Fibrosis Antibodies	>18 publications with DCD and Fibrosis