TNF-RII Antibody – Mouse Monoclonal

Product Description: The monoclonal antibody 80M2 recognizes the extracellular part of- membrane-bound TNF-RII as well as- the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist.- TNF-alpha is an important signaling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, whereas TNFRII exhibits more restricted expression, being found on certain subpopulations of immune cells and several other cell types. A dominant role of TNF-RII has been shown in thymocyte activation by TNF-alpha, whereas induction of cytotoxicity and other functions are mediated largely by TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is activated only by the membrane bound form of TNF-alpha. The antibody is a non-agonistic receptor modulating antibody. It enhances in vitro TNF alpha responses by increasing the affinity of the soluble form of TNF-alpha for TNF-RII.

1. Grell, M et al; The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 1995, 83: 793 2. Till, A et al; The Met 196 - Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha induced apoptosis by impaired NF-kB signalling and target gene expression. J Biol Chem 2005, 280: 5994
3. Scherubl C. et al; Colocalization of endogenous TNF with a functional intracellular splice form of human TNF receptor type 2. Journal of Inflammation 2005, 2: 7
4. Krippner, A et al; Single chain TNF, a TNF derivative with enhanced stability and antitumoral activity. J Immunol 2008, 180: 8176
5. Fairfax, B et al; A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance. J. Immonol 2011, 186: 3058

Small volumes of anti-TNF-RII antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS584282 is an antibody targeting TNF-RII. Also known as TNF-RII, Human, mAb 80M2. Reactive in Reactivity: Human. Cross reactivity: Rat. Host: Mouse.