RBC Antibody – Mouse Monoclonal

Product Description: The monoclonal antibody 34-3C recognizes an exposed surface determinant of intact red blood cells (RBC). The high-affinity anti-RBC monoclonal antibody efficiently bind to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity. The monoclonal antibody only recognises antigenic determinants expressed on Mouse RBC and not on other species of RBC.

1. Shibata, T et al; Monoclonal anti-erythrocyte autoantibodies derived from NZB mice cause autoimmune haemolytic anemia by two distinct pathogenic mechanisms. Int. Immun. 1990, 2:1133 2. Fossati-Jimack, L et al; High pathogenic potential of low-affinity autoantibodies in experimental autoimmune haemolytic anemia. J. Exp. Med. 1990, 190:1689
3. Fossati-Jimack, L et al; Selective increase of autoimmune epitope expression on aged erythrocytes in mice: Implications in anti-erythrocyte autoimmune responses. J. Autoimmun. 2002, 18:17
4. Azeredo da Silveira, S et al; Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high-affinity anti-erythrocyte autoantibody. J. Exp. Med. 2002, 195:665
5. Baudino, L et al; Differential contribution of three different activating IgG Fc receptors (FcyRI, FcyRIII and FcyRIV) to IgG2a- and IgG2b-induced autoimmune haemolytic anemia in mice. J. Immunol. 2008, 180:1948

Small volumes of anti-RBC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS584284 is an antibody targeting RBC. Also known as RBC, Mouse, mAb 34-3C. Reactive in Rat: No; Sheep: No; Rabbit: No; Chicken: No; Human: No. Host: Mouse.