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L-Afadin (MLLT4) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS584288

Product Description: Afadin is an actin filament-binding protein that is involved in cell-cell adherens junctions (AJs) which directly interacts with the alpha herpus virus receptor, a member of the immunoglobulin supergene family. Afadin is colocalized with… More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
L-Afadin (Mllt4), Monoclonal Antibody
Full Product Name
L-Afadin, Rat, mAb 3
Product Gene Name
anti-Mllt4 antibody
Clonality
Monoclonal
Isotype
Mouse IgG1
Host
Mouse
Species Reactivity
Reactivity: Rat. Cross reactivity: Canine, Human, Mouse
Form/Format
1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
Preparation and Storage
Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.
Molecular Weight
188,981 Da
Applications Tested/Suitable for anti-Mllt4 antibody
F, Immunoassay (IA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-Mllt4 antibody
Application Use: For Western blot and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Fixation with PFA or acetone/methanol is recommended.

Product References and Citations for anti-Mllt4 antibody

1. Sakisaka, T et al; Different behavior of l-afadin and neurabin-II during the formation and destruction of cell-cell adherens junction. Oncogene 1999, 18: 1609 2. Takahashi, K et al; Nectin/PRR: An immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with afadin, a PDZ domain-containing protein. J Cell Biol 1999, 145: 539

Other Notes

Small volumes of anti-Mllt4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mllt4 purchase

MBS584288 is an antibody targeting Mllt4. Also known as L-Afadin, Rat, mAb 3. Reactive in Reactivity: Rat. Cross reactivity: Canine, Human, Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Mllt4. It may not necessarily be applicable to this product.

NCBI GI #
2555011
NCBI GeneID
26955
NCBI Accession #
AAC53390.1
UniProt Secondary Accession #
O35890
UniProt Related Accession #
O35889
NCBI Official Full Name
l-Afadin
NCBI Official Synonym Full Names
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
NCBI Official Symbol
Mllt4
NCBI Official Synonym Symbols
Af6
UniProt Protein Name
Afadin
UniProt Synonym Protein Names
Protein Af-6
Protein Family
Afadin- and alpha-actinin-binding protein
UniProt Gene Name
Mllt4
UniProt Synonym Gene Names
Af6
UniProt Entry Name
AFAD_RAT
NCBI Protein Information
afadin; protein Af-6; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog

NCBI Summary for Mllt4

may play a role in linking the actin cytoskeleton to the plasma membrane [RGD, Feb 2006]

UniProt Comments for Mllt4

Afadin: plays a role in adhesion by participating, along with E-cadherin and catenin, in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Essential for the association of nectin and E-cadherin. Contains 1 forkhead-associated (FHA) domain, a phosphopeptide recognition domain; 1 dilute (DIL) domain, a myosin-like domain which may play a functional role in cellular processes or vectorial vesicle transport; 1 PDZ domain, which frequently binds the carboxyl-terminal sequences of proteins or phosphatidylinositol 4,5-bisphosphate in the plasma membrane; and 2 RA domains, which are associated with RasGTP effector activity. Five alternatively spliced isoforms have been described. Isoform 2 does not interact with F-actin.

Protein type: Oncoprotein; Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: nucleoplasm; adherens junction; cell-cell adherens junction; apical part of cell; cytoplasm; plasma membrane; intercellular junction; nucleus; cytosol; cell junction

Molecular Function: protein binding; LIM domain binding; Ras GTPase binding; cell adhesion molecule binding

Biological Process: cell adhesion; signal transduction
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Research Articles on Mllt4

1. afadin bi-directional shuttling from the cytosol to synapses and the nucleus promotes spine plasticity and histone modifications

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Mllt4 antibody

 Reference Product  PubMed Publications
 Pvrl1 antibody  >27 publications with Mllt4 and Pvrl1
 Tjp1 antibody  >14 publications with Mllt4 and Tjp1
 F11r antibody  >2 publications with Mllt4 and F11r
 Pvrl4 antibody  >1 publications with Mllt4 and Pvrl4
 Ssx2ip antibody  >1 publications with Mllt4 and Ssx2ip

Pathways associated with anti-Mllt4 antibody

 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 TCA Cycle Pathway antibodies  TCA Cycle Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram

Diseases associated with anti-Mllt4 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4 publications with Mllt4 and Breast Neoplasms
 Ovarian Diseases Antibodies  >2 publications with Mllt4 and Ovarian Diseases
 Disease Models, Animal Antibodies  >2 publications with Mllt4 and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >2 publications with Mllt4 and Ovarian Neoplasms
 Edema Antibodies  >2 publications with Mllt4 and Edema
 Infertility, Male Antibodies  >1 publications with Mllt4 and Infertility, Male
 Congenital Abnormalities Antibodies  >1 publications with Mllt4 and Congenital Abnormalities
 Lung Neoplasms Antibodies  >1 publications with Mllt4 and Lung Neoplasms
 Fibrosis Antibodies  >1 publications with Mllt4 and Fibrosis
 Inflammation Antibodies  >1 publications with Mllt4 and Inflammation
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