Alpha-V/Beta-3 Integrin Antibody – Mouse Monoclonal

The monoclonal antibody BV3 recognizes human alpha-V/beta-3 integrin present on human cells. Integrins are a superfamily of alphabeta heterodimeric cell-surface adhesion receptors found in many species. They are expressed on a variety of cells and mediate numerous physiological processes, including inflammation, migration, adhesion and proliferation. The β3 family consist of 2 members: αIIbβ3 and αvβ3, which mediate cell-cell and cell-ECM interactions and are important for cellular migration, regulation of gene expression, cell survival, adhesion and differentiation. All processes which are involved in tissue development, angiogenesis and thrombosis. Each subunit consist of an extracellular domain, a single transmembrane segment and a cytoplasmic tail. They connect to the actin cytoskeleton via adaptor proteins that bind theircytoplasmic tails. Cell matrix adhesions also act as signaling units by their capacity to organize the actin cytoskeleton and to accumulate various signaling intermediates. Integrin alphavbeta3 was originally identified as the vitronectin receptor. Nevertheless, other ligands include fibrinogen, fibronectin, laminin, thrombospondin, Von Willebrand factor, tenascin, osteopontin and several forms of collagen. The interactions of integrin αvβ3 to those ligands is mediated by the RGD (Arg-Gly-Asp) sequence motif present in these proteins. Deregulation of β3 integrins is involved in e.g. autoimmune diseases, cardiovascular disorders, transplant rejection and tumorigenesis. In contribution to the latter, integrin αvβ3 contribute by supporting growth of small (tumor) blood vessels thereby potentiating the metastatic potential. Overexpression of integrin αvβ3 has been demonstrated in various tumors and activated endothelium.

1. Newton, S et al.; Electroconvulsive seizure increases adult hippocampal angiogenesis in rats. Eur J neurosc. 2006, 24:819-828
2. Merkel, O et al.; Integrin alphavbeta3 targeted gene delivery using RGD peptidomimetic conjugates with copolymers of PRGylated poly(ethyleneimine). Bioconj chem.. 2009, 20:1270-1280
3. Dare, E et al.; Fibrin sealants from fresh/frozen plasma as scaffolds for in vitro articular cartilage regeneration. Tissue engineering, 2009, 15:2285

Small volumes of anti-alpha-V/beta-3 Integrin antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS584338 is an antibody targeting alpha-V/beta-3 Integrin. Also known as alpha-V/beta-3 Integrin, Human, mAb BV3. Reactive in Human. Host: Mouse.