MBL Antibody – Mouse Monoclonal

Product Description: Mannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q-independent. MBL exhibits complement-dependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of various vertebrate species.

1. Muto, S et al; Biological activities of human mannose-binding lectin bound to two different ligand sugar structures, Lewis A and Lewis B antigens and high-mannose type oligosaccharides. Biochimica et Biophysica Acta 2001, 1527: 39 2. Matsushita, M et al; Human mannose-binding protein is identical to a component of Ra-reactive factor. Biochem Biophys Res Commun 1992, 183: 645
3. Hisano, S et al; Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis. Am J Kidney Dis 2001, 38: 1082
4. Vries de, B et al; The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury. Am J Pathol 2004, 165: 1677
5. Nauta, A et al; Mannose-binding lectin engagement with late apoptotic and necrotic cells. Eur J Immunol 2003, 33 : 2853
6. Nauta, A et al ; Opsonization with C1q and Mannose-binding lectin targets apoptotic cells to dendritic cells. J Immunol 2004, 173: 3044

Small volumes of anti-MBL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS584398 is an antibody targeting MBL. Also known as MBL, Human, mAb 3E7, FITC. Reactive in Human. Host: Mouse.