Beta2-Adrenoceptor Antibody – Mouse Monoclonal

Product Description: The monoclonal antibody 6H8 recognizes human beta2-adrenoceptor. The b -adrenoceptors can be divided into b1, b2, b3 and b4-adrenoceptors defined in terms of agonist potencies, b2-adrenoceptors displayed a higher selectivity for nor-adrenaline than for adrenaline.
B2-receptors are mainly postsynaptic and are located on a number of tissues including blood vessels, bronchi, GIT, skeletal muscle, liver and mast cell. Activation results in vasodilatation, bronchodilation, relaxation of the GIT, glycogenolysis in the liver, tremor in skeletal muscle and inhibition of histamine release from mast cells.-
Transduction is via G-proteins coupled to the intracellular second messenger adenylate cyclase. B-receptors are positively coupled to adenylate cyclase via activation of Gs G-protein, however activation of the b2-adrenoceptors results in stimulation and inhibition of adenylate cyclase. The b2-receptor selective agonists are widely used in the treatment of asthma and other related bronchospastic conditions. They are commonly used in the treatment of angina pectoris, cardiac arrhythmia and for the long-term treatment of patients who survive myocardial infarction. B-receptor antagonists have also been used as anti-hypertensive for a number of years. Beta -blockers have also proven useful in the treatment of conditions such as migraine, anxiety disorders, hyperthyroidism, alcohol withdrawal and when applied topically are useful in the treatment of glaucoma and ocular hypertension.

1. Lebesgue, D et al; An agonist-like monoclonal antibody against the human beta2-adrenoceptor. Eur J Pharmacol 1998, 348: 123. 2. Mijares, A et al; From agonist to antagonist: Fab fragments of an agonistic-like monoclonal anti-beta2-adrenoceptor antibody behaves as antagonists. Mol Pharmacol 2000, 58: 373.

Small volumes of anti-Beta2-adrenoceptor antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS584424 is an antibody targeting Beta2-adrenoceptor. Also known as Beta2-adrenoceptor, Human, mAb 6H8. Reactive in Reactivity: Human. Cross reactivity: Guinea pig, Rat. Host: Mouse.