Soluble Mannose Receptor ELISA Kit for Human

Intended Uses: The soluble Mannose receptor (sMR) ELISA kit is to be used for the in vitro quantitative determination of sMR in plasma samples. This kit is intended for laboratory research use only. The analysis should be performed by trained laboratory professionals.

Background/Introduction: Recent studies have indicated increased concentrations of the soluble form of Mannose Receptor (MR) in plasma of patients with infection diseases such as sepsis, pneumonia and acute hepatitis. MR's are especially expressed on cell membranes of macrophages and function as Pattern Recognition Receptors (PRR). Exact function and (in-vivo) shedding-mechanism of the soluble form, soluble Mannose Receptor (sMR) is still unknown. Increased sMR's in plasma can be due to some pathogens in the body which stimulate the (in-vivo) shedding mechanism of the MR's. sMR's which are bound to the mannose residues of these pathogens, prevent it from being recognized and phagocyted by MR's. As a result, the innate immunity is slowly suppressed and a vicious circle (which increases the sMR's in plasma) is created. The body does this probably to partly slow the innate immunity to prevent going out of balance. When the disease being treated, the pathogens which are present in the body of the patient, will be less and less. In the body becoming less cleaved mannose receptors and the sMR in plasma will gradually decrease. The measurement of sMR's in plasma may be important for the identifys/monitoring of diseases such as sepsis, pneumonia and acute hepatitis.

Small volumes of Soluble mannose receptor elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS584844 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Soluble mannose receptor, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Soluble mannose receptor. The ELISA analytical biochemical technique of the MBS584844 kit is based on Soluble mannose receptor antibody-Soluble mannose receptor antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Soluble mannose receptor antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Soluble mannose receptor. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).