IP-10 Antibody – Mouse Monoclonal

The monoclonal antibody 6D4 recognizes human C-X-C motif chemokine 10 (IP-10), a protein of 98 amino acids. IP-10, also known as CXCL10, functions as ligand for the CXCR3 receptor. IP-10 belongs to the alpha-chemokine (C-X-C) family, which can be divided in two subfamilies: (1) potent chemoattractants for neutrophils, like IL-8 and (2) potent chemoattractants for lymphocytes, like the IFN? inducible protein (IP)-10. IP-10 is produced by a wide variety of cell types ranging from neutrophils, dendritic cells and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV, encephalitis, cutaneous T cell lymphoma, chronic hepatitis, psoriasis and acute anterior uveitis. Various observations strongly suggest a role for the C-X-C chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis. Furthermore IP-10 is associated with acute rejection processes estimated by the predictive properties of urinary IP-10 expression for the short- and long-term graft function after kidney transplantation.

1. Hamamdzic, D. et al; Reovirus triggers cell type-specific proinflammatory responses dependent on the autocrine action of IFNbeta. Am J Physiol Lung Cell Mol Physiol 2001, 280: L18
2. Giustizieri, M et al; Nitric oxide donors suppress chemokine production by keratinocytes in vitro and in vivo. Am J Path 2002, 161: 1409
3. Bendriss-Vermare, N et al; Virus overrides the propensity ofHuman CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-gamma and Th1 chemokine production. J of Leukoc Biol. 2005, 78: 954
4. Curbishley, S et al; CXCR3 activation promotes lymphocyte transendothelial migration acrossHuman hepatic endothelium under fluid flow. Am J Pathol 2005, 167: 887
5. Wetzel, M et al; u-Opioid Induction of Monocyte Chemoattractant Protein-1, RANTES, and IFN-g-Inducible Protein-10 Expression inHuman Peripheral Blood Mononuclear Cells. J Immunol 2000, 165: 6519

Small volumes of anti-IP-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS584865 is an antibody targeting IP-10. Also known as IP-10, Human, mAb 6D4, biotinylated. Reactive in Human. Host: Mouse.