Down Syndrome Cell Adhesion Molecule (DSCAM) Antibody – Mouse Monoclonal

Down syndrome cell adhesion molecule (Dscam) is a cell adhesion molecule that plays a role in neuronal self-avoidance. It promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Dscam mediates, within retinal amacrine and ganglion cell subtypes, both isoneuronal selfavoidance for creating an orderly dendritic arborization and heteroneuronal selfavoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. It is the receptor for netrin that is required for axon guidance independently of and in collaboration with the receptor DCC. In spinal cord development, it plays a role in guiding commissural axons during projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Dscam enhances netrin-induced phosphorylation of PAK1 and FYN. It mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Dscam interacts with DCC, Netrin-1, PAK1 and RAC1.

1. Yamagata M and Sanes JR-Dscam and Sidekick proteins direct lamina-specific synaptic connections invertebrate retina. Transfected human embryonic kidney 293 cells, overexpressing chicken Dscam or mouse Dscam, fixed with 4% paraformaldehyde/PBS. Cells are labeled with anti-Dscam antibody.

Small volumes of anti-DSCAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS588022 is an antibody targeting DSCAM. Also known as Down Syndrome Cell Adhesion Molecule (DSCAM) Antibody (DS2-176). Reactive in Chicken, Mouse. Host: Mouse.