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Chromogranin-A (CHGA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS588221

Chromogranin-A is a secreted protein known as a "prohormone" which is found in endocrine cells and neurons and may be released upon stimulation. It is thought to be involved in the formation of dense core granules, where it may be processed to form the… More details

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Product Overview

Product Name
Chromogranin-A (CHGA), Polyclonal Antibody
Full Product Name
Chromogranin-A (N-term) Rabbit Polyclonal Antibody
Product Gene Name
Product Synonym Names
hCGA; parathyroid secretory protein 1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mammals
Form/Format
Lyophilized Serum
Specificity
The antibody recognizes an epitope in N-terminal (AA 4-16) of Chromogranine-A
Preparation and Storage
Lyophilized antibody can be kept at 4 degree C for up to 3 months and should be kept at-20 degree C for long-term storage.
To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20 degree C) or for long-term storage (-80 degree C).
For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
50,688 Da
3D Structure
ModBase 3D Structure for P10645
Preservative
None
Applications Tested/Suitable for anti-CHGA antibody
Western Blot (WB)
Application Notes for anti-CHGA antibody
If reconstituted in 100 muL: WB: 1:2000.

Product References and Citations for anti-CHGA antibody

1. Fournier I-Processing of chromogranins/secretogranin in patients with diabetic retinopathy.

Other Notes

Small volumes of anti-CHGA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHGA purchase

MBS588221 is an antibody targeting CHGA. Also known as Chromogranin-A (N-term) Rabbit Polyclonal Antibody. Reactive in Human, Mammals. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHGA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
chromogranin-A isoform 1 preproprotein
NCBI Official Synonym Full Names
chromogranin A
NCBI Official Symbol
CHGA
NCBI Official Synonym Symbols
CGA
UniProt Protein Name
Chromogranin-A
UniProt Synonym Protein Names
Pituitary secretory protein I; SP-I
Protein Family
UniProt Gene Name
CHGA
UniProt Synonym Gene Names
CgA; SP-I
NCBI Protein Information
chromogranin-A

NCBI Summary for CHGA

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
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UniProt Comments for CHGA

Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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