Amyloid Precursor Protein Cleaved by Caspase-6 Antibody – Rabbit Polyclonal

Amyloid precursor protein (APP) functions as a cell surface receptor in the synapses of neurons and is implicated in neurite growth, neuronal adhesion, axonogenesis and cell mobility. APP is known as the precursor molecule whose proteolysis generates beta amyloid. Defects in APP are the cause of Alzheimer's disease type 1 and of amyloidosis cerebroarterial. Caspase activation has been found to have a central role in neuronal death and chronic neurodegenerations such as Huntington's, Parkinson's and Alzheimer's diseases. Proteolytic cleavage of specific substrates has also been demonstrated to be an important cellular event in the pathogenesis of AD and inhibition of cleavage of APP by caspase-6 was demonstrated to suppress synapse loss, dentate gyral atrophy, and memory loss.

Small volumes of anti-Amyloid Precursor Protein Cleaved By Caspase-6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS588238 is an antibody targeting Amyloid Precursor Protein Cleaved By Caspase-6. Also known as Amyloid Precursor Protein Cleaved By Caspase-6 Rabbit Polyclonal Antibody. Reactive in Human. Host: Rabbit.