Clathrin Light Chain (Clca/Clcb) (CLCa/CLCb) Antibody – Rabbit Polyclonal

Clathrin-coated vesicles (CCVs) are the major carriers for uptake of nutrients and signalling receptors and for the reformation of synaptic vesicles. Pathogens co-opt the endocytic pathway to gain access into cells. Clathrin is the major component of CCVs and is composed of clathrin-heavy chain and clathrin-light chain (CLC). CLC is a reliable marker of clathrin-coated structures and is also used as a marker of the presynaptic nerve terminal in neurons. Both CLCa and CLCb have alternatively spliced isoforms that are differentially expressed in tissues.

1. Allaire PD-Connecdenn, a novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis. 2. Ybe JA-Clathrin self-assembly is regulated by three light-chain residues controlling the formation of critical salt bridges. 3. Girard M-Non-stoichiometric relationship between clathrin heavy and light chains revealed by quantitative comparative proteomics of clathrin-coated vesicles. 4. Hayashi M-Cell-and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons. 5. Poupon V-Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly.

Small volumes of anti-CLCa/CLCb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS588253 is an antibody targeting CLCa/CLCb. Also known as Clathrin Light Chain (CLCa/CLCb) Rabbit Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.