• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Proenkephalin-A (PEA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS588298

Vertebrate endogenous opioid neuropeptides are released by post-translational proteolytic cleavage of precursor proteins. Proenkephalin-A is one of the three opioid neuropeptide precursor molecules of the opioid pentapeptides Met-and Leu-enkephalin, which… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
Proenkephalin-A (PEA), Polyclonal Antibody
Full Product Name
Proenkephalin-A (N-term) Rabbit Polyclonal Antibody
Product Gene Name
Product Synonym Names
Proenkephalin; PENK
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized serum
Preparation and Storage
Lyophilized antibody can be kept at 4 degree C for up to 3 months and should be kept at-20 degree C for long-term storage.
To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20 degree C) or for long-term storage (-80 degree C).
For maximum recovery of product centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
30,787 Da
3D Structure
ModBase 3D Structure for P01210
Immunogen
Immunogen: N-terminal peptide (AA 63-70)
Preservative
None
Applications Tested/Suitable for anti-PEA antibody
Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-PEA antibody
If reconstituted in 100 muL: WB: 1:1000-1:2000; IP 10 pi of serum.

Product References and Citations for anti-PEA antibody

1. Goumon Y-Processing of proenkephalin-A in bovine chromaffin cells. Identification of natural derived fragments by N-terminal sequencing and matrix-assisted.

Other Notes

Small volumes of anti-PEA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PEA purchase

MBS588298 is an antibody targeting PEA. Also known as Proenkephalin-A (N-term) Rabbit Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PEA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
proenkephalin-A preproprotein
NCBI Official Synonym Full Names
proenkephalin
NCBI Official Symbol
PENK
NCBI Official Synonym Symbols
PE; PENK-A
UniProt Protein Name
Proenkephalin-A
UniProt Synonym Protein Names
SynenkephalinMet-enkephalinAlternative name(s):Opioid growth factor; OGF
Protein Family
UniProt Gene Name
PENK
UniProt Synonym Gene Names
OGF
NCBI Protein Information
proenkephalin-A

NCBI Summary for PEA

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
Show more

UniProt Comments for PEA

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000