Amyloid Beta Peptide 42 Antibody – Mouse Monoclonal

Description:Description: Mouse monoclonal antibody to C-terminus of amyloid beta peptide 42 (Aβ42).

BackgroundAmyloid beta peptide 42 (Aβ42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Aβ42 and Aβ40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Aβ42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Aβ42 consitituents the intial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Aβ42 contibutes to the pathogenesis of Alzheimer's. One propsition is that the deposition of amyloid fibril onto the brain tissues results in Alzheimer's disease. Another is that the neurotoxicity of Aβ42 oligomer is the cause of the disease.

Small volumes of anti-Amyloid Beta Peptide 42 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS592143 is an antibody targeting Amyloid Beta Peptide 42. Also known as mAb anti-Amyloid Beta Peptide 42. Reactive in Human and other primates; mouse, rat. Host: Mouse.