2nd Extracellular Loop (FPRL1) Antibody – Mouse Monoclonal

Description: Mouse monoclonal antibody against the 2nd extracellular loop of human formyl peptide-receptor-like-1 (FPRL1)

background: Human formyl peptide receptor-like 1(FPRL1) is a G-protein coupled seven transmembrane receptor. The receptor can bind to the formyl peptides derived from the degradation of the cell wall of infected bacteria and host cells. FPRL1 expressed on the cell surface of neutrophils and other leukocytes mediates the chemotaxis of these cells toward infected site. It has been reported that acute phase protein SAA is also a ligand of FPRL1 and SAA can induce the secretion of IL-8 and TNF-alpha by neutrophil through FPRL1 signalling. FPRL1 has also been shown to mediate the chemotaxis of microglia by Abeta42 peptide and the internalization of Abeta42 peptide into cytoplasma of macrophage, indicating that FRPL1 may participate in the Abeta42 peptide elicited pathogenesis in Alzheimer's disease.

Small volumes of anti-FPRL1 2nd extracellular loop antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS592376 is an antibody targeting FPRL1 2nd extracellular loop. Also known as mAb anti-Human FPRL1 2nd extracellular loop. Reactive in Human. Host: Mouse.