Beta Amyloid Peptide 42 (AB42) Antibody – Mouse Monoclonal

Description: Mouse monoclonal antibody to Cterminal of amyloid beta peptide 42 (Abeta42)

Background: Amyloid beta peptide 42 (Abeta42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Abeta42 and Abeta40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Abeta42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Abeta42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Abeta42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of Abeta42 oligomer is the cause of the disease.

Small volumes of anti-Ab42 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS592412 is an antibody targeting Ab42. Also known as mAb anti- Amyloid Beta Peptide 42. Reactive in Human and other primates; mouse and rat.. Host: Mouse.