Mouse Anti-IL-17A Monoclonal Antibody – Cat# MBS592430

The image below shows that anti-human IL-17A antibody 4C1 reacts with human cell expressed human IL-17A antigen (250 ng)in Western blot. The blot was stained with HRP substrate 4-Chloro-4-naphtol.

IL-17A Antibody – Mouse Monoclonal

Name: IL-17A Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS592430
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS592430

IL-17A is an inflammatory cytokine produced by Th17 cells, a newly characterised group of CD4 T help cells that plays a role in autoimmune diseases and chronic inflammatory diseases. IL-23 is the main inducer of Th17 cell development. Other cytokines such as… More details

$405 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL-17A, Monoclonal Antibody

Full Product Name

Mouse monoclonal antibody to human IL-17A

Product Gene Name

anti-IL-17A antibody

Product Synonym Names

mAb anti Human IL-17A clone 4C1; Mouse monoclonal antibody to human interleukin-17A (IL-17A)

Clonality

Monoclonal

Isotype

IgG1 Kappa

Clone Number

4C1

Host

Mouse

Species Reactivity

Human, others no tested.

Form/Format

Lyophilized from a solution in 0.01M PBS, pH 7.0

Purity/Purification

Protein G affinity purified

Specificity

Reactive with recombinant human IL-17A

Preparation and Storage

Store at -20°C

OMIM

Z58820 mRNA

3D Structure

ModBase 3D Structure for Q16552

Target Protein

Human IL-17A

Immunogen

Purified, human cell expressed recombinant human IL-17A

Fusion Myeloma

SP2/0

Reconstitution

Double distilled water is recommended to reconstitute the antibody to 1mg/mL.

Research Area

Cytokine. Inflammatory and auto-immune diseases

Product Categories/Family for anti-IL-17A antibody

Cytokine; inflammatory and auto-immune responses

ISO Certification

Manufactured in an ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-IL-17A antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-IL-17A antibody

Sandwich ELISA: In combination with biotin conjugated anti-human IL-17A clone 3H11 MBS592444, anti- human IL-17A clone 4C1 can be used as capture antibody for quantitative measurement of human IL-17A in sandwich ELISA application.

Other Notes

Small volumes of anti-IL-17A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-17A purchase

MBS592430 is an antibody targeting IL-17A. Also known as Mouse monoclonal antibody to human IL-17A. Reactive in Human, others no tested.. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-17A. It may not necessarily be applicable to this product.

NCBI GI #

4504651

NCBI GeneID

3605

NCBI Accession #

NP_002181.1

UniProt Primary Accession #

Q16552

UniProt Secondary Accession #

Q5T2P0

UniProt Related Accession #

Q16552

GenBank Nucleotide #

NM_002190.2

NCBI Official Full Name

interleukin-17A

NCBI Official Synonym Full Names

interleukin 17A

NCBI Official Symbol

IL17A

NCBI Official Synonym Symbols

IL17; CTLA8; IL-17; CTLA-8; IL-17A

UniProt Protein Name

Interleukin-17A

UniProt Synonym Protein Names

Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

Protein Family

Interleukin

UniProt Gene Name

IL17A

UniProt Synonym Gene Names

CTLA8; IL17; IL-17; IL-17A; CTLA-8

NCBI Protein Information

interleukin-17A

NCBI Summary for IL-17A

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

UniProt Comments for IL-17A

IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p12.2

Cellular Component: extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; protein binding

Biological Process: apoptosis; cell death; cell surface receptor linked signal transduction; cell-cell signaling; immune response; inflammatory response; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter

Research Articles on IL-17A

1. We determined that IL-17A-induced VEGF upregulation and neovascularization through a Stat3-mediated signaling pathway and hypothesized that blocking the Stat3 activation by using JSI-124, an inhibitor of phosphorylated Stat3, could significantly reduce the VEGF expression and can thus prevent angiogenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL-17A antibody

Reference Product	PubMed Publications
FOXP3 antibody	>105 publications with IL-17A and FOXP3
IL6 antibody	>96 publications with IL-17A and IL6
STAT3 antibody	>54 publications with IL-17A and STAT3
IL17RA antibody	>38 publications with IL-17A and IL17RA
IL22 antibody	>29 publications with IL-17A and IL22
TGFB1 antibody	>25 publications with IL-17A and TGFB1
STAT1 antibody	>19 publications with IL-17A and STAT1
IL17RC antibody	>13 publications with IL-17A and IL17RC
TRAF3IP2 antibody	>7 publications with IL-17A and TRAF3IP2
NFKB1 antibody	>5 publications with IL-17A and NFKB1

Pathways associated with anti-IL-17A antibody

Products by Pathway	Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Development And Heterogeneity Of The ILC Family Pathway antibodies	Development And Heterogeneity Of The ILC Family Pathway Diagram
IL17 Signaling Pathway antibodies	IL17 Signaling Pathway Diagram
IL23-mediated Signaling Events Pathway antibodies	IL23-mediated Signaling Events Pathway Diagram
IL27-mediated Signaling Events Pathway antibodies	IL27-mediated Signaling Events Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram

Diseases associated with anti-IL-17A antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>481 publications with IL-17A and Inflammation
Autoimmune Diseases Antibodies	>262 publications with IL-17A and Autoimmune Diseases
Disease Models, Animal Antibodies	>201 publications with IL-17A and Disease Models, Animal
Necrosis Antibodies	>175 publications with IL-17A and Necrosis
Lung Diseases Antibodies	>143 publications with IL-17A and Lung Diseases
Hypersensitivity Antibodies	>88 publications with IL-17A and Hypersensitivity
Cardiovascular Diseases Antibodies	>79 publications with IL-17A and Cardiovascular Diseases
Colitis Antibodies	>66 publications with IL-17A and Colitis
Central Nervous System Diseases Antibodies	>64 publications with IL-17A and Central Nervous System Diseases
Liver Diseases Antibodies	>39 publications with IL-17A and Liver Diseases

Organs/Tissues associated with anti-IL-17A antibody

Organ/Tissue Name	Pubmed Publications
Mixed Antibodies	>19 publications with IL-17A and Mixed