Mouse Anti-PD-1 Monoclonal Antibody – Cat# MBS592453

Programmed Cell Death-1 (PD-1) Antibody – Mouse Monoclonal

Name: PD-1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS592453
Price: 390 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS592453

Programmed Cell Death-1 (PD-1), also called CD279, is a 288 amino acid cell surface protein that belongs to the immunoglobulin superfamily. More details

$390 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Programmed cell death-1 (PD-1), Monoclonal Antibody

Full Product Name

Mouse monoclonal antibody to human programmed cell death-1 (PD-1)

Product Gene Name

anti-PD-1 antibody

Product Synonym Names

mAb anti-Human programmed cell death-1; Mouse monoclonal antibody (mAb) to human programmed cell death-1 (PD-1), or mouse mAb to human CD279.

Clonality

Monoclonal

Isotype

IgG1,k

Clone Number

2H7

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized from a solution in 0.01M PBS, pH 7.2

Purity/Purification

Protein G affinity purified

Specificity

Reactive with recombinant human programmed cell death-1 (PD-1). Reactivity with natural PD-1 has not been evaluated.

Preparation and Storage

Store at -20 degree C

Molecular Weight

31,647 Da

OMIM

109100

Target Protein

Human programmed cell death-1 (PD-1)

Immunogen

40kDa recombinant human programmed cell death-1 (PD-1) from ACRO Biosystems

Myeloma

Sp2/0-Ag14

Light Chain

Kappa

Reconstitution

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Product Categories/Family for anti-PD-1 antibody

Immunosuppression

ISO Certification

Manufactured in an ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-PD-1 antibody

ELSIA (EIA)

Other Notes

Small volumes of anti-PD-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PD-1 purchase

MBS592453 is an antibody targeting PD-1. Also known as Mouse monoclonal antibody to human programmed cell death-1 (PD-1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PD-1. It may not necessarily be applicable to this product.

NCBI GI #

119591704

NCBI GeneID

5133

NCBI Accession #

EAW71298.1

UniProt Secondary Accession #

O00517; Q8IX89

UniProt Related Accession #

Q15116

NCBI Official Full Name

programmed cell death 1

NCBI Official Synonym Full Names

programmed cell death 1

NCBI Official Symbol

PDCD1

NCBI Official Synonym Symbols

PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1

UniProt Protein Name

Programmed cell death protein 1

UniProt Synonym Protein Names

CD_antigen: CD279

UniProt Gene Name

PDCD1

UniProt Synonym Gene Names

PD1; Protein PD-1; hPD-1

NCBI Protein Information

programmed cell death protein 1

NCBI Summary for PD-1

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

UniProt Comments for PD-1

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.

Research Articles on PD-1

1. The data we presented here showed that CTLA-4 was highly expressed in regulatory T cells and PD-1 decreased in CD8+ T cells in peripheral blood of SCLC patients, suggesting their unique mechanisms involved in immune regulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PD-1 antibody

Reference Product	PubMed Publications
CD274 antibody	>756 publications with PD-1 and CD274
CD4 antibody	>676 publications with PD-1 and CD4
PDCD1LG2 antibody	>134 publications with PD-1 and PDCD1LG2
PTPN11 antibody	>8 publications with PD-1 and PTPN11
PTPN6 antibody	>7 publications with PD-1 and PTPN6
LCK antibody	>4 publications with PD-1 and LCK
HLA-DRB1 antibody	>4 publications with PD-1 and HLA-DRB1
CD3E antibody	>2 publications with PD-1 and CD3E
HLA-DRA antibody	>1 publications with PD-1 and HLA-DRA

Pathways associated with anti-PD-1 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
PD-1 Signaling Pathway antibodies	PD-1 Signaling Pathway Diagram
T Cell Receptor Signaling Pathway antibodies	T Cell Receptor Signaling Pathway Diagram
T Cell Receptor Signaling Pathway antibodies	T Cell Receptor Signaling Pathway Diagram
T-Cell Receptor And Co-stimulatory Signaling Pathway antibodies	T-Cell Receptor And Co-stimulatory Signaling Pathway Diagram
T-Cell Antigen Receptor (TCR) Pathway During Staphylococcus Aureus Infection antibodies	T-Cell Antigen Receptor (TCR) Pathway During Staphylococcus Aureus Infection Diagram

Diseases associated with anti-PD-1 antibody

Disease Name	Pubmed Publications
Melanoma Antibodies	>386 publications with PD-1 and Melanoma
Lung Neoplasms Antibodies	>275 publications with PD-1 and Lung Neoplasms
Lung Diseases Antibodies	>272 publications with PD-1 and Lung Diseases
Liver Diseases Antibodies	>224 publications with PD-1 and Liver Diseases
Inflammation Antibodies	>224 publications with PD-1 and Inflammation
Adenocarcinoma Antibodies	>167 publications with PD-1 and Adenocarcinoma
Necrosis Antibodies	>165 publications with PD-1 and Necrosis
Kidney Diseases Antibodies	>88 publications with PD-1 and Kidney Diseases
Cardiovascular Diseases Antibodies	>80 publications with PD-1 and Cardiovascular Diseases
Liver Neoplasms Antibodies	>63 publications with PD-1 and Liver Neoplasms

Organs/Tissues associated with anti-PD-1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1678 publications with PD-1 and Blood
Kidney Antibodies	>91 publications with PD-1 and Kidney