Hepatitis B E Recombinant Protein

The hepatitis B virus is major cause for human liver disease, chronic infection usually causes liver cancer and cirrhosis. The outer viron is covered by a layer derived from endoplasmic reticulum and virus-encoded surface protein. Inside of this layer encloses the viral nucleocapside, i.e. core antigen which contains the viral genome. The capsid consists of dimmers of a 183-residue protein, which can be divided into a fragment (1-149) responsible for assembling and a basic residue-composed domain responsible for polymerization into particle and RNA packaging, respectively. This recombinant e antigen consists of HBV e immunodominant region containing 10 precore residues at its N-terminus and 1-149 residues from the end of precore to its C-terminus. It was expressed from E Coli, the purified recombinant core antigen can be used for ELISA assay and Western blot for clinical study and research. Some times, virus like particle can be found from over 30% E Coli expressed viral antigen, multiple antigens can aggregate into one large particle, even though with reducing condition, multiplized proteins, such as dimer, trimer is still present on SDS-PAGE. Aggregated virus like particle has strong ability in immunal reaction, they can be used for vaccine study or generate better result in immunoassay for identification.

Small volumes of Hepatitis B e recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS596020 is a recombinant protein targeting Hepatitis B e. Also known as Virus like particle formed by recombinant hepatitis B virus e antigen. Host: E Coli.