Hepatitis B Virus Pre-S (PRE-S) Recombinant Protein

Hepatitis B virus surface gene encodes small(HBs), middle (MHBs) and large (LHBs) surface protein.These proteins are translated from distinct start codons, butshare a common reading frame and stop codon. HBs has 226amino acids, a major viral envelope component. MHBs hasextra 55 amino acids (Pre-S2) located to its N-terminal of ofHBs, LHBs is with an additional 119 amino acids (Pre-S1).
Pre-S is a region containing Pre-S1 and S2, Pre-S1 plays animportant role in receptor recognition, while Pre-S2 plays arole in translocation of virus into host cell. Clinically, HBVpre-S is associated with HBsAg and HBV DNA copies,indicating active replication of virus, reduction of pre-S isusually associating with decreased HBV DNA copies, itindicates an improved predictor of treatment. Pre-S is also apotential vaccine under development to supplement currentlyused HBsAg vaccine.

Small volumes of Pre-S recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS596058 is a recombinant protein targeting Pre-S. Also known as Hepatitis B virus Pre-S (Pre-S1 + Pre-S2). Host: E Coli.