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Rho Gdp Dissociation Inhibitor Alpha (ARHGDIA) ELISA Kit for Monkey

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS005963

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of ARHGDIA (hereafter termed "analyte") in undiluted original Monkey body fluids, tissue homogenates,… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Rho Gdp Dissociation Inhibitor Alpha (ARHGDIA), ELISA Kit
Full Product Name
Monkey Rho Gdp Dissociation Inhibitor Alpha ELISA Kit
Product Gene Name
ARHGDIA elisa kit
Species Reactivity
Monkey
Assay Type
Sandwich (Quantitative)
Detection Range
0.25ng/ml-8ng/ml.
Sensitivity
0.1ng/ml.
Specificity
No significant cross-reactivity or interference between this analyte and analogues is observed.
Preparation and Storage
Store all reagents at 2-8 degree C
Inter-assay Precision
Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
Intra-assay Precision
Intra-assay CV (%) is less than 15%.
Molecular Weight
23,207 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (79825597..79829282, complement). Location: 17q25.3
OMIM
601925
3D Structure
ModBase 3D Structure for P52565

Other Notes

Small volumes of ARHGDIA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARHGDIA purchase

MBS005963 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Rho Gdp Dissociation Inhibitor Alpha (ARHGDIA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ARHGDIA. The ELISA analytical biochemical technique of the MBS005963 kit is based on ARHGDIA antibody-ARHGDIA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ARHGDIA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ARHGDIA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGDIA. It may not necessarily be applicable to this product.

NCBI GI #
48145671
NCBI GeneID
396
NCBI Accession #
CAG33058.1
UniProt Primary Accession #
P52565
UniProt Secondary Accession #
Q6IBM5; A8MXW0; B2R5X1; B4DDD3; B4DUV9
UniProt Related Accession #
P52565
NCBI Official Full Name
ARHGDIA
NCBI Official Synonym Full Names
Rho GDP dissociation inhibitor (GDI) alpha
NCBI Official Symbol
ARHGDIA
NCBI Official Synonym Symbols
GDIA1; NPHS8; RHOGDI; RHOGDI-1
UniProt Protein Name
Rho GDP-dissociation inhibitor 1
UniProt Synonym Protein Names
Rho-GDI alpha
UniProt Gene Name
ARHGDIA
UniProt Synonym Gene Names
GDIA1; Rho GDI 1
UniProt Entry Name
GDIR1_HUMAN
NCBI Protein Information
rho GDP-dissociation inhibitor 1; rho GDI 1; rho-GDI alpha

NCBI Summary for ARHGDIA

Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 [PubMed 8262133]).[supplied by OMIM, Jan 2009]
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UniProt Comments for ARHGDIA

RhoGDI alpha: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Monomer. Forms a heterodimer with RAC1. Interacts with FER. Belongs to the Rho GDI family.

Protein type: Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis; Apoptosis

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: cytoskeleton; immunological synapse; cytosol

Molecular Function: protein binding; Rho GDP-dissociation inhibitor activity; GTPase activator activity

Biological Process: nerve growth factor receptor signaling pathway; negative regulation of cell adhesion; regulation of axonogenesis; Rho protein signal transduction; regulation of small GTPase mediated signal transduction; regulation of protein localization; small GTPase mediated signal transduction; positive regulation of axonogenesis; negative regulation of axonogenesis; cell motility; negative regulation of cell migration; positive regulation of GTPase activity; negative regulation of apoptosis

Disease: Nephrotic Syndrome, Type 8
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Research Articles on ARHGDIA

1. demonstrate that membrane extraction of Rho GTPase by RhoGDI is a thermodynamically favored passive process that operates through a series of progressively tighter intermediates, much like the one that is mediated by RabGDI

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ARHGDIA elisa kit

 Reference Product  PubMed Publications
 RHOA elisa kit  >41 publications with ARHGDIA and RHOA
 RAC1 elisa kit  >30 publications with ARHGDIA and RAC1
 CDC42 elisa kit  >28 publications with ARHGDIA and CDC42
 BCR elisa kit  >3 publications with ARHGDIA and BCR
 RAC2 elisa kit  >2 publications with ARHGDIA and RAC2
 NGFR elisa kit  >1 publications with ARHGDIA and NGFR

Pathways associated with ARHGDIA elisa kit

 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Axonal Growth Stimulation Pathway antibodies  Axonal Growth Stimulation Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 RAC1 Signaling Pathway antibodies  RAC1 Signaling Pathway Diagram
 Regulation Of CDC42 Activity Pathway antibodies  Regulation Of CDC42 Activity Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram

Diseases associated with ARHGDIA elisa kit

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with ARHGDIA and Neoplasms
 Neoplasm Metastasis Antibodies  >8 publications with ARHGDIA and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >5 publications with ARHGDIA and Adenocarcinoma
 Brain Diseases Antibodies  >4 publications with ARHGDIA and Brain Diseases
 Cardiovascular Diseases Antibodies  >4 publications with ARHGDIA and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >4 publications with ARHGDIA and Nervous System Diseases
 Breast Neoplasms Antibodies  >4 publications with ARHGDIA and Breast Neoplasms
 Lung Diseases Antibodies  >3 publications with ARHGDIA and Lung Diseases
 Proteinuria Antibodies  >3 publications with ARHGDIA and Proteinuria
 Kidney Diseases Antibodies  >2 publications with ARHGDIA and Kidney Diseases

Organs/Tissues associated with ARHGDIA elisa kit

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with ARHGDIA and Brain
 Muscle Antibodies  >7 publications with ARHGDIA and Muscle
 Blood Antibodies  >6 publications with ARHGDIA and Blood
 Kidney Antibodies  >5 publications with ARHGDIA and Kidney
 Lung Antibodies  >4 publications with ARHGDIA and Lung
 Bone Marrow Antibodies  >3 publications with ARHGDIA and Bone Marrow
 Vascular Antibodies  >3 publications with ARHGDIA and Vascular
 Heart Antibodies  >3 publications with ARHGDIA and Heart
 Bone Antibodies  >3 publications with ARHGDIA and Bone
 Eye Antibodies  >2 publications with ARHGDIA and Eye
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