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SLC6A5 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6000024

This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in… More details

$880 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SLC6A5, Monoclonal Antibody
Full Product Name
SLC6A5 (GLYT2, NET1, Sodium-and Chloride-dependent Glycine Transporter 2, Solute Carrier Family 6 Member 5)
Product Gene Name
anti-SLC6A5 antibody
Product Synonym Names
Anti -SLC6A5 (GLYT2, NET1, Sodium-and Chloride-dependent Glycine Transporter 2, Solute Carrier Family 6 Member 5)
Immunogen Sequence
TLFYLFASFV SVLPWGSCNN PWNTPECKDK TKLLLDSCVI SDHPKIQIKN STFCMTAYPN VTMVNFTSQA NKTFVSGSEE YFKYFVLKIS AGIEYPGEIR
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
3B3
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SLC6A5.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
87,434 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (20620946..20676610). Location: 11p15.1
OMIM
604159
3D Structure
ModBase 3D Structure for Q9Y345
Immunogen
Partial recombinant corresponding to aa294-394 from SLC6A5 (NP_004202) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-SLC6A5 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-SLC6A5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SLC6A5 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-SLC6A5 antibody

Western Blot detection against Immunogen (37.11kD).
Mouse Anti-SLC6A5 Monoclonal Antibody – Cat# MBS6000024

Other Notes

Small volumes of anti-SLC6A5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC6A5 purchase

MBS6000024 is an antibody targeting SLC6A5. Also known as SLC6A5 (GLYT2, NET1, Sodium-and Chloride-dependent Glycine Transporter 2, Solute Carrier Family 6 Member 5). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC6A5. It may not necessarily be applicable to this product.

NCBI GI #
92859670
NCBI GeneID
9152
NCBI Accession #
NP_004202.2
UniProt Primary Accession #
Q9Y345
UniProt Secondary Accession #
O95288; Q4VAM7; Q9BX77
UniProt Related Accession #
Q9Y345
GenBank Nucleotide #
NM_004211.3
NCBI Official Full Name
sodium- and chloride-dependent glycine transporter 2
NCBI Official Synonym Full Names
solute carrier family 6 (neurotransmitter transporter), member 5
NCBI Official Symbol
SLC6A5
NCBI Official Synonym Symbols
NET1; GLYT2; HKPX3; GLYT-2
UniProt Protein Name
Sodium- and chloride-dependent glycine transporter 2
UniProt Synonym Protein Names
Solute carrier family 6 member 5
Protein Family
Sodium- and chloride-dependent glycine transporter
UniProt Gene Name
SLC6A5
UniProt Synonym Gene Names
GLYT2; NET1; GlyT-2; GlyT2
UniProt Entry Name
SC6A5_HUMAN
NCBI Protein Information
sodium- and chloride-dependent glycine transporter 2; solute carrier family 6 (neurotransmitter transporter, glycine), member 5

UniProt Comments for SLC6A5

SLC6A5: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses. Defects in SLC6A5 are the cause of hyperekplexia type 3 (HKPX3). HKPX3 is a neurologic disorder characterized by neonatal hypertonia, an exaggerated startle response to tactile or acoustic stimuli, and life- threatening neonatal apnea episodes. Notably, in some cases, symptoms resolved in the first year of life. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A5 subfamily.

Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: neurotransmitter:sodium symporter activity; glycine:sodium symporter activity

Biological Process: synaptic transmission; synaptic transmission, glycinergic; transport; neurotransmitter transport; transmembrane transport

Disease: Hyperekplexia 3
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Research Articles on SLC6A5

1. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC6A5 antibody

 Reference Product  PubMed Publications
 GLRA1 antibody  >14 publications with SLC6A5 and GLRA1
 STX1A antibody  >4 publications with SLC6A5 and STX1A
 SDCBP antibody  >1 publications with SLC6A5 and SDCBP

Pathways associated with anti-SLC6A5 antibody

 Products by Pathway  Pathway Diagram
 Na+/Cl- Dependent Neurotransmitter Transporters Pathway antibodies  Na+/Cl- Dependent Neurotransmitter Transporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram

Diseases associated with anti-SLC6A5 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >1 publications with SLC6A5 and Carcinoma
 Adenocarcinoma Antibodies  >1 publications with SLC6A5 and Adenocarcinoma

Organs/Tissues associated with anti-SLC6A5 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >76 publications with SLC6A5 and Brain
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