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STK17B Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS600004

DRAK2 (DAP kinase related apoptosis inducing protein kinase 2) is a member of the novel DAP (death associated protein) pro-apoptotic kinase family (1). Overexpression of DRAK2 in NIH/3T3 cells induces morphological changes associated with apoptosis, which are… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DRAK2 (STK17B), Monoclonal Antibody
Full Product Name
DRAK2, CT (DAP Kinase-related Apoptosis-inducing Protein Kinase 2)
Product Gene Name
anti-STK17B antibody
Product Synonym Names
Anti -DRAK2, CT (DAP Kinase-related Apoptosis-inducing Protein Kinase 2)
Clonality
Monoclonal
Isotype
IgG
Clone Number
7H19
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol and less than 0.02% sodium azide.
Purity/Purification
Supernatant
Supernatant
Specificity
Species Crossreactivity: Mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
42,344 Da
Chromosome Location
chromosome: 2; Location: 2q32.3
OMIM
604727
3D Structure
ModBase 3D Structure for O94768
Immunogen
Synthetic peptide (KLH-coupled) corresponding to residues surrounding Asp315 of mouse DRAK2.

Product Categories/Family for anti-STK17B antibody

Antibodies; Abs to Apoptosis
Applications Tested/Suitable for anti-STK17B antibody
ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Application Notes for anti-STK17B antibody
Suitable for use in Flow Cytometry, ELISA, Western Blot and Immunoprecipitation.,
Dilution: Flow Cytometry: 1:200
Western Blot: 1:1000
Immunoprecipitation: 1:50

Western Blot (WB) of anti-STK17B antibody

Western blot analysis of total cell lysates from BaF3 and mouse thymocytes, using MBS600004 DRAK2.
Rabbit Anti-STK17B Monoclonal Antibody – Cat# MBS600004

Immunohistochemistry (IHC) of anti-STK17B antibody

Immunohistochemical analysis of paraffin-embedded mouse thymus, using MBS600004.
Rabbit Anti-STK17B Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS600004

Flow Cytometry (FC/FACS) of anti-STK17B antibody

Flow cytometric analysis of BaF3 cells, using MBS600004 DRAK2 (blue) compared to a nonspecific negative control antibody (red).
Rabbit Anti-STK17B Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS600004

Other Notes

Small volumes of anti-STK17B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STK17B purchase

MBS600004 is an antibody targeting STK17B. Also known as DRAK2, CT (DAP Kinase-related Apoptosis-inducing Protein Kinase 2). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STK17B. It may not necessarily be applicable to this product.

NCBI GI #
3834356
NCBI GeneID
9262
UniProt Primary Accession #
O94768
UniProt Related Accession #
O94768; Q53QE7; Q6FG83; Q6FG98
NCBI Official Full Name
DRAK2
NCBI Official Synonym Full Names
serine/threonine kinase 17b
NCBI Official Symbol
STK17B
NCBI Official Synonym Symbols
DRAK2; STK17B
UniProt Protein Name
Serine/threonine-protein kinase 17B
UniProt Synonym Protein Names
DAP kinase-related apoptosis-inducing protein kinase 2
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
STK17B
UniProt Synonym Gene Names
DRAK2
UniProt Entry Name
ST17B_HUMAN
NCBI Protein Information
serine/threonine-protein kinase 17B; death-associated protein kinase-related 2; DAP kinase-related apoptosis-inducing protein kinase 2

UniProt Comments for STK17B

DRAK2: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; CAMK group; DAPK family

Chromosomal Location of Human Ortholog: 2q32.3

Cellular Component: plasma membrane; ER-Golgi intermediate compartment; nucleus; actin cytoskeleton

Molecular Function: protein serine/threonine kinase activity; ATP binding; protein kinase activity

Biological Process: apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation
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Research Articles on STK17B

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
2. Observational study of gene-disease association. (HuGE Navigator)
3. Strong suppression of T cell receptor signals during thymic selection caused by ectopic DRAK2 expression in a DRAK2 transgenic mouse model of autoimmune encephalomyelitis alters the responsiveness of peripheral T cells.
4. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer.
5. DRAK2 kinase activity is regulated in a calcium-dependent manner and that Ser(12) phosphorylation is necessary for optimal suppression of T cell activation by this kinase
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STK17B antibody

 Reference Product  PubMed Publications
 CHP antibody  >2 publications with STK17B and CHP

Diseases associated with anti-STK17B antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >7 publications with STK17B and Death
 Neoplasms Antibodies  >6 publications with STK17B and Neoplasms
 Drug Toxicity Antibodies  >2 publications with STK17B and Drug Toxicity
 Skin Diseases Antibodies  >1 publications with STK17B and Skin Diseases
 Breast Neoplasms Antibodies  >1 publications with STK17B and Breast Neoplasms
 Lymphoma Antibodies  >1 publications with STK17B and Lymphoma
 Lymphoma, Non-Hodgkin Antibodies  >1 publications with STK17B and Lymphoma, Non-Hodgkin
 Testicular Diseases Antibodies  >1 publications with STK17B and Testicular Diseases
 Autistic Disorder Antibodies  >1 publications with STK17B and Autistic Disorder
 Cell Transformation, Neoplastic Antibodies  >1 publications with STK17B and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-STK17B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with STK17B and Blood
 Brain Antibodies  >3 publications with STK17B and Brain
 Spleen Antibodies  >2 publications with STK17B and Spleen
 Thymus Antibodies  >1 publications with STK17B and Thymus
 Skin Antibodies  >1 publications with STK17B and Skin
 Testis Antibodies  >1 publications with STK17B and Testis
 Kidney Antibodies  >1 publications with STK17B and Kidney
 Intestine Antibodies  >1 publications with STK17B and Intestine
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