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OBFC2B (NABP2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6000248

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by… More details

$895 / 0.2 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
OBFC2B (NABP2), Polyclonal Antibody
Full Product Name
OBFC2B, CT (NABP2, OBFC2B, SSB1, SOSS complex subunit B1, Nucleic acid-binding protein 2, Oligonucleotide/oligosaccharide-binding fold-containing protein 2B, Sensor of single-strand DNA complex subunit B1, Sensor of ssDNA subunit B1, Single-stranded DNA-b
Product Gene Name
anti-NABP2 antibody
Product Synonym Names
Anti -OBFC2B, CT (NABP2, OBFC2B, SSB1, SOSS complex subunit B1, Nucleic acid-binding protein 2, Oligonucleotide/oligosaccharide-binding fold-containing protein 2B, Sensor of single-strand DNA complex subunit B1, Sensor of ssDNA subunit B1, Single-stranded DNA-b
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
22,338 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (56615813..56623638). Location: 12q13.3
OMIM
612104
3D Structure
ModBase 3D Structure for Q9BQ15
Immunogen
OBFC2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-211 amino acids from the C-terminal region of human OBFC2B.

Product Categories/Family for anti-NABP2 antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-NABP2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-NABP2 antibody
Suitable for use in Western Blot, ELISA
Western Blot: 1:100-500
Optimal dilutions to be determined by the researcher.
Other applications not tested.

Western Blot (WB) of anti-NABP2 antibody

OBFC2B Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the OBFC2B antibody detected the OBFC2B protein (arrow).
Rabbit Anti-NABP2 Polyclonal Antibody – Cat# MBS6000248

Other Notes

Small volumes of anti-NABP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NABP2 purchase

MBS6000248 is an antibody targeting NABP2. Also known as OBFC2B, CT (NABP2, OBFC2B, SSB1, SOSS complex subunit B1, Nucleic acid-binding protein 2, Oligonucleotide/oligosaccharide-binding fold-containing protein 2B, Sensor of single-strand DNA complex subunit B1, Sensor of ssDNA subunit B1, Single-stranded DNA-b. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NABP2. It may not necessarily be applicable to this product.

NCBI GI #
13544080
NCBI GeneID
79035
NCBI Accession #
AAH06171.1
UniProt Primary Accession #
Q9BQ15
UniProt Secondary Accession #
Q6XYC8; A6NDF8
UniProt Related Accession #
Q9BQ15
NCBI Official Full Name
OBFC2B protein
NCBI Official Synonym Full Names
nucleic acid binding protein 2
NCBI Official Symbol
NABP2
NCBI Official Synonym Symbols
SSB1; hSSB1; OBFC2B; SOSS-B1
UniProt Protein Name
SOSS complex subunit B1
UniProt Synonym Protein Names
Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; SOSS-B1; Single-stranded DNA-binding protein 1
Protein Family
SOSS complex
UniProt Gene Name
NABP2
UniProt Synonym Gene Names
OBFC2B; SSB1; SOSS-B1; hSSB1
UniProt Entry Name
SOSB1_HUMAN
NCBI Protein Information
SOSS complex subunit B1; LP3587; sensor of ssDNA subunit B1; nucleic acid-binding protein 2; single strand DNA-binding protein 1; single-stranded DNA-binding protein 1; sensor of single-strand DNA complex subunit B1; oligonucleotide/oligosaccharide-binding fold containing 2B; oligonucleotide/oligosaccharide-binding fold-containing protein 2B

NCBI Summary for NABP2

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

UniProt Comments for NABP2

OBFC2B: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Component of the SOSS complex, composed of SOSS-B (SOSS- B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. SOSS complexes containing SOSS-B1/OBFC2B are more abundant than complexes containing SOSS-B2/OBFC2A. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7. Belongs to the SOSS-B family. SOSS-B1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; DNA repair, damage

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; single-stranded DNA binding

Biological Process: mitotic cell cycle checkpoint; response to ionizing radiation; DNA repair; response to DNA damage stimulus; double-strand break repair via homologous recombination
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Research Articles on NABP2

1. SOSS complexes, containing SSB1, do not localize with Replication Protein A (RPA) to replication sites in human cells, yet have a strong effect on double-strand break resection and homologous recombination.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NABP2 antibody

 Reference Product  PubMed Publications
 ATM antibody  >1 publications with NABP2 and ATM

Organs/Tissues associated with anti-NABP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with NABP2 and Blood
 Thyroid Antibodies  >1 publications with NABP2 and Thyroid
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