Rat Anti-EGR1 Monoclonal Antibody – Cat# MBS600052

EGR1 Antibody – Rat Monoclonal

Name: EGR1 Antibody; Monoclonal; Rat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS600052
Price: 1030 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS600052

Early Growth Response 1, (EGR1) belongs to the EGR family of zinc finger transcription factors and regulates the expression of several tumor suppressors. Its expression is induced by diverse signals that initiate growth and differentiation. EGR1 suppresses or… More details

$1030 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EGR1, Monoclonal Antibody

Full Product Name

EGR1 (Zif268, Early Growth Response Protein 1, Krox-24, NGFI-A, TIS8, ZENK)

Product Gene Name

anti-EGR1 antibody

Product Synonym Names

Anti -EGR1 (Zif268, Early Growth Response Protein 1, Krox-24, NGFI-A, TIS8, ZENK)

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

7H231

Host

Rat

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human EGR1.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

57,507 Da

Chromosome Location

Chromosome: 5; NC_000005.9 (137801181..137805004). Location: 5q31.1

OMIM

128990

3D Structure

ModBase 3D Structure for P18146

Immunogen

E. coli-derived recombinant human EGR1 (aa282-433, Accession #NP_001955)

Product Categories/Family for anti-EGR1 antibody

Antibodies; Abs to Transcription Factors; Zinc (Ring) Finger

Applications Tested/Suitable for anti-EGR1 antibody

ELISA (EL/EIA), Immunohistochemistry (IHC)

Application Notes for anti-EGR1 antibody

Suitable for use in Immunohistochemistry and ELISA.
Dilution: Immunohistochemistry:15ug/ml and using basic antigen retrieval detected EGR1 in paraffin-embedded human prostate cancer tissue sections.

Other Notes

Small volumes of anti-EGR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EGR1 purchase

MBS600052 is an antibody targeting EGR1. Also known as EGR1 (Zif268, Early Growth Response Protein 1, Krox-24, NGFI-A, TIS8, ZENK). Reactive in Human. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for EGR1. It may not necessarily be applicable to this product.

NCBI GI #

4503493

NCBI GeneID

1958

NCBI Accession #

NP_001955.1

UniProt Primary Accession #

P18146

UniProt Related Accession #

P18146; Q546S1

GenBank Nucleotide #

NM_001964.2

NCBI Official Full Name

early growth response protein 1

NCBI Official Synonym Full Names

early growth response 1

NCBI Official Symbol

EGR1

NCBI Official Synonym Symbols

TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268

UniProt Protein Name

Early growth response protein 1

UniProt Synonym Protein Names

AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24

Protein Family

Early growth response protein

UniProt Gene Name

EGR1

UniProt Synonym Gene Names

KROX24; ZNF225

UniProt Entry Name

EGR1_HUMAN

NCBI Protein Information

early growth response protein 1; EGR-1; OTTHUMP00000159483; zinc finger protein 225; transcription factor ETR103; transcription factor Zif268; zinc finger protein Krox-24; nerve growth factor-induced protein A

NCBI Summary for EGR1

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq]

UniProt Comments for EGR1

EGR1: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. By growth factors. Belongs to the EGR C2H2-type zinc-finger protein family.

Protein type: DNA-binding; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: histone acetyltransferase binding; protein binding; DNA binding; sequence-specific DNA binding; metal ion binding; double-stranded DNA binding; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; response to nutrient levels; circadian rhythm; regulation of long-term neuronal synaptic plasticity; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; response to amphetamine; negative regulation of transcription from RNA polymerase II promoter; response to cocaine; BMP signaling pathway; response to ethanol; learning and/or memory; cellular response to insulin stimulus; positive regulation of neuron apoptosis; response to glucose stimulus; oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; response to electrical stimulus; negative regulation of apoptosis; regulation of protein sumoylation; T cell differentiation

Research Articles on EGR1

1. The study suggests a connection between CD133 and EGR1 and emphasises the importance of the EGR1/TCF4/CD133/LGR5 network in colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EGR1 antibody

Reference Product	PubMed Publications
JUN antibody	>281 publications with EGR1 and JUN

Pathways associated with anti-EGR1 antibody

Products by Pathway	Pathway Diagram
Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies	Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Downstream Signaling In Naive CD8+ T Cells Pathway antibodies	Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
ErbB1 Downstream Signaling Pathway antibodies	ErbB1 Downstream Signaling Pathway Diagram
Glucocorticoid Receptor Regulatory Network Pathway antibodies	Glucocorticoid Receptor Regulatory Network Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Interferon Signaling Pathway antibodies	Interferon Signaling Pathway Diagram

Diseases associated with anti-EGR1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>448 publications with EGR1 and Neoplasms
Inflammation Antibodies	>117 publications with EGR1 and Inflammation
Cardiovascular Diseases Antibodies	>114 publications with EGR1 and Cardiovascular Diseases
Necrosis Antibodies	>110 publications with EGR1 and Necrosis
Leukemia Antibodies	>94 publications with EGR1 and Leukemia
Leukemia, Myeloid Antibodies	>60 publications with EGR1 and Leukemia, Myeloid
Adenocarcinoma Antibodies	>58 publications with EGR1 and Adenocarcinoma
Mental Disorders Antibodies	>55 publications with EGR1 and Mental Disorders
Lung Diseases Antibodies	>52 publications with EGR1 and Lung Diseases
Prostatic Neoplasms Antibodies	>52 publications with EGR1 and Prostatic Neoplasms

Organs/Tissues associated with anti-EGR1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>612 publications with EGR1 and Brain
Blood Antibodies	>329 publications with EGR1 and Blood
Nerve Antibodies	>232 publications with EGR1 and Nerve
Vascular Antibodies	>206 publications with EGR1 and Vascular
Muscle Antibodies	>164 publications with EGR1 and Muscle
Kidney Antibodies	>108 publications with EGR1 and Kidney
Lung Antibodies	>101 publications with EGR1 and Lung
Liver Antibodies	>89 publications with EGR1 and Liver
Heart Antibodies	>85 publications with EGR1 and Heart
Bone Antibodies	>78 publications with EGR1 and Bone