Mouse Anti-CCR6 Monoclonal Antibody – Cat# MBS600067

CCR6 Antibody – Mouse Monoclonal

Name: CCR6 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS600067
Price: 655 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS600067

CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this… More details

$655 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCR6, Monoclonal Antibody

Full Product Name

CCR6 (Chemokine Receptor 6, CC-CCR-6)

Product Gene Name

anti-CCR6 antibody

Product Synonym Names

Anti -CCR6 (Chemokine Receptor 6, CC-CCR-6)

Clonality

Monoclonal

Isotype

IgG1k

Clone Number

8j7

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human CCR6.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

42,494 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (167525295..167552629). Location: 6q27

OMIM

601835

3D Structure

ModBase 3D Structure for P51684

Immunogen

Recombinant human CCR6 (1-46aa) purified from E. coli

Hybridoma

FO myeloma cells with spleen cells from Balb/c mice.

Product Categories/Family for anti-CCR6 antibody

Antibodies; Abs to G Proteins

Applications Tested/Suitable for anti-CCR6 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-CCR6 antibody

Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:500-1:1000

Other Notes

Small volumes of anti-CCR6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCR6 purchase

MBS600067 is an antibody targeting CCR6. Also known as CCR6 (Chemokine Receptor 6, CC-CCR-6). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CCR6. It may not necessarily be applicable to this product.

NCBI GI #

37188165

NCBI GeneID

1235

NCBI Accession #

NP_113597.2

UniProt Primary Accession #

P51684

UniProt Secondary Accession #

P78553; Q92846; E1P5C6

UniProt Related Accession #

P51684; Q53EZ5

GenBank Nucleotide #

NM_031409.3

NCBI Official Full Name

C-C chemokine receptor type 6

NCBI Official Synonym Full Names

chemokine (C-C motif) receptor 6

NCBI Official Symbol

CCR6

NCBI Official Synonym Symbols

BN-1; DCR2; DRY6; CCR-6; CD196; CKRL3; GPR29; CKR-L3; CMKBR6; GPRCY4; STRL22; CC-CKR-6; C-C CKR-6

UniProt Protein Name

C-C chemokine receptor type 6

UniProt Synonym Protein Names

Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; GPR-CY4; GPRCY4; LARC receptor

Protein Family

C-C chemokine receptor

UniProt Gene Name

CCR6

UniProt Synonym Gene Names

CKRL3; CMKBR6; GPR29; STRL22

UniProt Entry Name

CCR6_HUMAN

NCBI Protein Information

C-C chemokine receptor type 6; LARC receptor; OTTHUMP00000017618; OTTHUMP00000017619; chemokine receptor-like 3; chemokine (C-C) receptor 6; G protein-coupled receptor 29; G-protein coupled receptor 29; seven-transmembrane receptor, lymphocyte, 22

NCBI Summary for CCR6

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq]

UniProt Comments for CCR6

CCR6: Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cellular defense response; dendritic cell chemotaxis; innate immune response; immune response; cell motility; chemotaxis; signal transduction; humoral immune response

Research Articles on CCR6

1. CCL20 induces MUC5AC mucin production via CCR6- and tumor necrosis factor (TNF)-alpha-converting enzyme (TACE)-dependent epidermal growth factor receptor (EGFR) activation in human airway epithelial (NCI-H292) cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCR6 antibody

Reference Product	PubMed Publications
CCL20 antibody	>267 publications with CCR6 and CCL20
DEFB4A antibody	>17 publications with CCR6 and DEFB4A
DEFB1 antibody	>3 publications with CCR6 and DEFB1

Pathways associated with anti-CCR6 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-CCR6 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>164 publications with CCR6 and Inflammation
Neoplasms Antibodies	>100 publications with CCR6 and Neoplasms
Arthritis, Rheumatoid Antibodies	>48 publications with CCR6 and Arthritis, Rheumatoid
Carcinoma Antibodies	>46 publications with CCR6 and Carcinoma
Adenocarcinoma Antibodies	>23 publications with CCR6 and Adenocarcinoma
Encephalomyelitis, Autoimmune, Experimental Antibodies	>20 publications with CCR6 and Encephalomyelitis, Autoimmune, Experimental
Neoplasm Metastasis Antibodies	>19 publications with CCR6 and Neoplasm Metastasis
Respiratory Hypersensitivity Antibodies	>17 publications with CCR6 and Respiratory Hypersensitivity
Liver Neoplasms Antibodies	>15 publications with CCR6 and Liver Neoplasms
Dermatitis, Contact Antibodies	>11 publications with CCR6 and Dermatitis, Contact

Organs/Tissues associated with anti-CCR6 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>429 publications with CCR6 and Blood
Lymph Node Antibodies	>82 publications with CCR6 and Lymph Node
Intestine Antibodies	>59 publications with CCR6 and Intestine
Bone Marrow Antibodies	>42 publications with CCR6 and Bone Marrow
Spleen Antibodies	>35 publications with CCR6 and Spleen
Thymus Antibodies	>21 publications with CCR6 and Thymus
Pharynx Antibodies	>12 publications with CCR6 and Pharynx
Stomach Antibodies	>6 publications with CCR6 and Stomach
Prostate Antibodies	>2 publications with CCR6 and Prostate