NOXA1 Antibody – Rabbit Polyclonal

This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

NOXA1: Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. Belongs to the NCF2/NOXA1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Activator

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cytoplasm; NADPH oxidase complex

Molecular Function: protein binding; enzyme binding; Rac GTPase binding; superoxide-generating NADPH oxidase activator activity; SH3 domain binding

Biological Process: positive regulation of catalytic activity; superoxide metabolic process; regulation of hydrogen peroxide metabolic process