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LAMTOR5 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6000764

As part of the Ragulator complex it is involved in aa sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by aa through a mechanism involving the lysosomal… More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HBXIP (LAMTOR5), Monoclonal Antibody
Full Product Name
HBXIP (LAMTOR5, Ragulator Complex Protein LAMTOR5, Hepatitis B Virus X-interacting Protein, HBV X-interacting Protein, HBX-interacting Protein, Late Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 5, XIP)
Product Gene Name
anti-LAMTOR5 antibody
Product Synonym Names
Anti -HBXIP (LAMTOR5, Ragulator Complex Protein LAMTOR5, Hepatitis B Virus X-interacting Protein, HBV X-interacting Protein, HBX-interacting Protein, Late Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 5, XIP)
Immunogen Sequence
MEATLEQHLE DTMKNPSIVG VLCTDSQGLN LGCRGTLSDE HAGVISVLAQ QAAKLTSDPT DIPVVCLESD NGNIMIQKHD GITVAAHKMA S
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
4G1
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human HBXIP.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
9,614 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (110943875..110950546, complement). Location: 1p13.3
OMIM
608521
3D Structure
ModBase 3D Structure for O43504
Immunogen
Full-length recombinant protein corresponding to aa83-173 from HBXIP (AAH62619) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-LAMTOR5 antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-LAMTOR5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-LAMTOR5 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-LAMTOR5 antibody

Western Blot detection against Immunogen (36.12kD).
Mouse Anti-LAMTOR5 Monoclonal Antibody – Cat# MBS6000764

Western Blot (WB) of anti-LAMTOR5 antibody

Western Blot analysis of HBXIP expression in transfected 293T cell line by HBXIP monoclonal antibody.|Lane 1: HBXIP transfected lysate (10.12kD).|Lane 2: Non-transfected lysate.
Mouse Anti-LAMTOR5 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6000764

Testing Data of anti-LAMTOR5 antibody

Detection limit for recombinant GST tagged HBXIP is 0.03ng/ml as a capture antibody.
Mouse Anti-LAMTOR5 Monoclonal Antibody, Testing Data – Cat# MBS6000764

Other Notes

Small volumes of anti-LAMTOR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LAMTOR5 purchase

MBS6000764 is an antibody targeting LAMTOR5. Also known as HBXIP (LAMTOR5, Ragulator Complex Protein LAMTOR5, Hepatitis B Virus X-interacting Protein, HBV X-interacting Protein, HBX-interacting Protein, Late Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 5, XIP). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for LAMTOR5. It may not necessarily be applicable to this product.

NCBI GI #
49457256
NCBI GeneID
10542
NCBI Accession #
CAG46927.1
UniProt Primary Accession #
O43504
UniProt Secondary Accession #
Q6IBD8
UniProt Related Accession #
O43504
NCBI Official Full Name
HBXIP
NCBI Official Synonym Full Names
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
NCBI Official Symbol
LAMTOR5
NCBI Official Synonym Symbols
XIP; HBXIP
UniProt Protein Name
Ragulator complex protein LAMTOR5
UniProt Synonym Protein Names
Hepatitis B virus X-interacting protein; HBV X-interacting protein; HBX-interacting protein; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
Protein Family
Ragulator complex protein
UniProt Gene Name
LAMTOR5
UniProt Synonym Gene Names
HBXIP; XIP; HBV X-interacting protein
UniProt Entry Name
LTOR5_HUMAN
NCBI Protein Information
ragulator complex protein LAMTOR5; HBx-interacting protein; HBV X-interacting protein; hepatitis B virus x interacting protein; hepatitis B virus x-interacting protein (9.6kD); late endosomal/lysosomal adaptor and MAPK and MTOR activator 5

NCBI Summary for LAMTOR5

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

UniProt Comments for LAMTOR5

HBXIP: When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. Belongs to the HBXIP family.

Protein type: Apoptosis; DNA replication

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: lysosome; cytosol

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; protein complex scaffold

Biological Process: response to virus; viral genome replication; negative regulation of caspase activity; regulation of cell size; positive regulation of TOR signaling pathway; positive regulation of GTPase activity; negative regulation of apoptosis
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Research Articles on LAMTOR5

1. HBXIP nuclear import requires interaction with c-Fos and phosphorylation of both proteins in breast cancer cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-LAMTOR5 antibody

 Products by Pathway  Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
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