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MAN1A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6001064

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2. More details

$970 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MAN1A1, Polyclonal Antibody
Full Product Name
MAN1A1 (Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, Man(9)-alpha-mannosidase, Man9-mannosidase, Mannosidase alpha Class 1A Member 1, Processing alpha-1,2-mannosidase IA, Alpha-1,2-mannosidase IA)
Product Gene Name
anti-MAN1A1 antibody
Product Synonym Names
Anti -MAN1A1 (Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, Man(9)-alpha-mannosidase, Man9-mannosidase, Mannosidase alpha Class 1A Member 1, Processing alpha-1,2-mannosidase IA, Alpha-1,2-mannosidase IA)
Immunogen Sequence
MPVGGLLPLF SSPAGGVLGG GLGGGGGRKG SGPAALRLTE KFVLLLVFSA FITLCFGAIF FLPDSSKLLS GVLFHSSPAL QPAADHKPGP GARAEDAAEG RARRREEGAP GDPEAALEDN LARIRENHER ALREAKETLQ KLPEEIQRDI LLEKKKVAQD QLRDKAPFRG LPPVDFVPPI GVESREPADA AIREKRAKIK EEIEARKGQA NCPGSSSSCE VEIQMMKHAW NNYKGYAWGL NELKPISKGG HSSSLFGNIK GATIVDALDT LFIMEMKHEF EEAKSWVEEN LDFNVNAEIS VFEVNIRFVG GLLSAYYLSG EEIFRKKAVE LGVKLLPAFH TPSGIPWALL NMKRWMCNIP RAMEATI
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human MAN1A1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
72,969 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (119498366..119671774, complement). Location: 6q22
OMIM
604344
3D Structure
ModBase 3D Structure for P33908
Immunogen
Full length human MAN1A1, aa1-367 (AAH65827.1).

Product Categories/Family for anti-MAN1A1 antibody

Antibodies; Abs to Enzymes
Applications Tested/Suitable for anti-MAN1A1 antibody
Western Blot (WB)
Application Notes for anti-MAN1A1 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-MAN1A1 antibody

MAN1A1 rabbit polyclonal antibody. Western Blot analysis of MAN1A1 expression in A-431.
Rabbit Anti-MAN1A1 Polyclonal Antibody – Cat# MBS6001064

Western Blot (WB) of anti-MAN1A1 antibody

Western Blot analysis of MAN1A1 expression in transfected 293T cell line by MAN1A1 polyclonal antibody. Lane 1: MAN1A1 transfected lysate (40kD). Lane 2: Non-transfected lysate.
Rabbit Anti-MAN1A1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6001064

Other Notes

Small volumes of anti-MAN1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAN1A1 purchase

MBS6001064 is an antibody targeting MAN1A1. Also known as MAN1A1 (Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, Man(9)-alpha-mannosidase, Man9-mannosidase, Mannosidase alpha Class 1A Member 1, Processing alpha-1,2-mannosidase IA, Alpha-1,2-mannosidase IA). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAN1A1. It may not necessarily be applicable to this product.

NCBI GI #
41351377
NCBI GeneID
4121
NCBI Accession #
AAH65827.1
UniProt Primary Accession #
P33908
UniProt Secondary Accession #
Q9NU44; Q9UJI3
UniProt Related Accession #
P33908
NCBI Official Full Name
MAN1A1 protein
NCBI Official Synonym Full Names
mannosidase, alpha, class 1A, member 1
NCBI Official Symbol
MAN1A1
NCBI Official Synonym Symbols
MAN9; HUMM3; HUMM9
UniProt Protein Name
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
UniProt Synonym Protein Names
Man(9)-alpha-mannosidase; Man9-mannosidase; Mannosidase alpha class 1A member 1; Processing alpha-1,2-mannosidase IA
Protein Family
Mannosyl-oligosaccharide 1,2-alpha-mannosidase
UniProt Gene Name
MAN1A1
UniProt Synonym Gene Names
Man9-mannosidase
UniProt Entry Name
MA1A1_HUMAN
NCBI Protein Information
mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; Man9-mannosidase; alpha-1,2-mannosidase IA; man(9)-alpha-mannosidase; processing alpha-1,2-mannosidase IA

NCBI Summary for MAN1A1

This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
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UniProt Comments for MAN1A1

MAN1A1: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Belongs to the glycosyl hydrolase 47 family.

Protein type: Hydrolase; EC 3.2.1.113; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Endoplasmic reticulum; Calcium-binding

Chromosomal Location of Human Ortholog: 6q22

Cellular Component: Golgi membrane; Golgi apparatus; membrane; endoplasmic reticulum; cytoplasm; ER-Golgi intermediate compartment; integral to membrane

Molecular Function: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding; mannosidase activity

Biological Process: cellular protein metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
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Research Articles on MAN1A1

1. Complex N-glycans generated by enzymes such as a-mannosidase I inhibit the activation of naive T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MAN1A1 antibody

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-glycan Precursor Trimming Pathway antibodies  N-glycan Precursor Trimming Pathway Diagram
 N-glycan Precursor Trimming Pathway antibodies  N-glycan Precursor Trimming Pathway Diagram
 N-glycan Trimming And Elongation In The Cis-Golgi Pathway antibodies  N-glycan Trimming And Elongation In The Cis-Golgi Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Progressive Trimming Of Alpha-1,2-linked Mannose Residues From Man9/8/7GlcNAc2 To Produce Man5GlcNAc2 Pathway antibodies  Progressive Trimming Of Alpha-1,2-linked Mannose Residues From Man9/8/7GlcNAc2 To Produce Man5GlcNAc2 Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-MAN1A1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with MAN1A1 and Neoplasms
 Breast Neoplasms Antibodies  >1 publications with MAN1A1 and Breast Neoplasms

Organs/Tissues associated with anti-MAN1A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with MAN1A1 and Kidney
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