Rabbit Anti-USP14 Polyclonal Antibody – Cat# MBS6001067

USP14 Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the USP14 antibody detected the USP14 protein (arrow).

USP14 Antibody – Rabbit Polyclonal

Name: USP14 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6001067
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6001067

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

USP14, Polyclonal Antibody

Full Product Name

USP14, CT (USP14, TGT, Ubiquitin carboxyl-terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14)

Product Gene Name

anti-USP14 antibody

Product Synonym Names

Anti -USP14, CT (USP14, TGT, Ubiquitin carboxyl-terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

56,069 Da

Chromosome Location

Chromosome: 18; NC_000018.9 (158483..213739). Location: 18p11.32

OMIM

607274

3D Structure

ModBase 3D Structure for P54578

Immunogen

USP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-383 amino acids from the C-terminal region of human USP14.

Product Categories/Family for anti-USP14 antibody

Antibodies; Abs to Ubiquitin

Applications Tested/Suitable for anti-USP14 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-USP14 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-USP14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for USP14 purchase

MBS6001067 is an antibody targeting USP14. Also known as USP14, CT (USP14, TGT, Ubiquitin carboxyl-terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for USP14. It may not necessarily be applicable to this product.

NCBI GI #

82880645

NCBI GeneID

9097

NCBI Accession #

NP_001032411.1

UniProt Primary Accession #

P54578

UniProt Secondary Accession #

Q53XY5; J3QRZ5

UniProt Related Accession #

P54578

GenBank Nucleotide #

NM_001037334.1

NCBI Official Full Name

ubiquitin carboxyl-terminal hydrolase 14 isoform b

NCBI Official Synonym Full Names

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

NCBI Official Symbol

USP14

NCBI Official Synonym Symbols

TGT

UniProt Protein Name

Ubiquitin carboxyl-terminal hydrolase 14

UniProt Synonym Protein Names

Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14

UniProt Gene Name

USP14

UniProt Synonym Gene Names

TGT

UniProt Entry Name

UBP14_HUMAN

NCBI Protein Information

ubiquitin carboxyl-terminal hydrolase 14; ubiquitin thioesterase 14; deubiquitinating enzyme 14; ubiquitin thiolesterase 14; ubiquitin-specific processing protease 14; ubiquitin-specific-processing protease 14; tRNA-guanine transglycosylase, 60-kD subunit; ubiquitin specific protease 14 (tRNA-guanine transglycosylase)

UniProt Comments for USP14

USP14: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Belongs to the peptidase C19 family. USP14/UBP6 subfamily.

Protein type: Ubiquitin-specific protease; Ubiquitin conjugating system; EC 3.4.19.12; Protease

Chromosomal Location of Human Ortholog: 18p11.32

Cellular Component: proteasome complex; cell surface; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; synapse; nucleus

Molecular Function: tRNA guanylyltransferase activity; protein binding; cysteine-type endopeptidase activity; endopeptidase inhibitor activity; ubiquitin-specific protease activity

Biological Process: synaptic transmission; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; regulation of chemotaxis

Research Articles on USP14

1. overexpression of HA-USP14 increased the LPS-, TNFalpha-, or Escherichia coli-induced IL-8 release in human lung epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-USP14 antibody

Reference Product	PubMed Publications
UCHL5 antibody	>8 publications with USP14 and UCHL5

Diseases associated with anti-USP14 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>7 publications with USP14 and Neoplasms
Disease Models, Animal Antibodies	>4 publications with USP14 and Disease Models, Animal
Ovarian Diseases Antibodies	>2 publications with USP14 and Ovarian Diseases
Brain Diseases Antibodies	>2 publications with USP14 and Brain Diseases
Inflammation Antibodies	>2 publications with USP14 and Inflammation
Liver Neoplasms Antibodies	>2 publications with USP14 and Liver Neoplasms
Atrophy Antibodies	>2 publications with USP14 and Atrophy
Liver Diseases Antibodies	>2 publications with USP14 and Liver Diseases
Immune System Diseases Antibodies	>1 publications with USP14 and Immune System Diseases
Weight Loss Antibodies	>1 publications with USP14 and Weight Loss

Organs/Tissues associated with anti-USP14 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>7 publications with USP14 and Brain
Lung Antibodies	>2 publications with USP14 and Lung
Testis Antibodies	>1 publications with USP14 and Testis