Mouse Anti-ECE2 Polyclonal Antibody – Cat# MBS6001343

Western Blot analysis of ECE2 expression in transfected 293T cell line by ECE2 polyclonal antibody. Lane 1: ECE2 transfected lysate (28.05kD). Lane 2: Non-transfected lysate.

ECE2 Antibody – Mouse Polyclonal

Name: ECE2 Antibody; Polyclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6001343
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6001343

Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide… More details

$880 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ECE2, Polyclonal Antibody

Full Product Name

ECE2 (Endothelin-converting Enzyme 2, ECE-2, Methyltransferase-like Region, Endothelin-converting Enzyme 2 Region, KIAA0604, UNQ403/PRO740)

Product Gene Name

anti-ECE2 antibody

Product Synonym Names

Anti -ECE2 (Endothelin-converting Enzyme 2, ECE-2, Methyltransferase-like Region, Endothelin-converting Enzyme 2 Region, KIAA0604, UNQ403/PRO740)

Immunogen Sequence

MASPGAGRAP PELPERNCGY REVEYWDQRY QGAADSAPYD WFGDFSSFRA LLEPELRPED RILVLGCGNS ALSYELFLGG FPNVTSVDYS SVVVAAMQAR YAHVPQLRWE TMDVRKLDFP SASFDVVLEK GTLDALLAGE RDPWTVSSEG VHTVDQVLSE VSRVLVPGGR FISMTSAAPH FRTRHYAQAY YGWSLRHATY GSGFHFHLYL MHKGGKLSVA QLALGAQILS PPRPPTSPCF LQDSDHEDFL SAIQL

Clonality

Polyclonal

Isotype

IgG

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human ECE2.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

99,773 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (183967445..184010819). Location: 3q27.1; .

OMIM

610145

3D Structure

ModBase 3D Structure for O60344

Immunogen

Full length human ECE2, aa1-255 (NP_115707).

Product Categories/Family for anti-ECE2 antibody

Antibodies; Abs to Enzymes; Methyltransferase

Applications Tested/Suitable for anti-ECE2 antibody

Western Blot (WB)

Application Notes for anti-ECE2 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-ECE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ECE2 purchase

MBS6001343 is an antibody targeting ECE2. Also known as ECE2 (Endothelin-converting Enzyme 2, ECE-2, Methyltransferase-like Region, Endothelin-converting Enzyme 2 Region, KIAA0604, UNQ403/PRO740). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ECE2. It may not necessarily be applicable to this product.

NCBI GI #

153945836

NCBI GeneID

9718

NCBI Accession #

NP_001093591.1

UniProt Primary Accession #

O60344

UniProt Secondary Accession #

Q6NTG7; Q6UW36; Q8NFD7; Q96NX3; Q96NX4; Q9BRZ8; A5PLK8

UniProt Related Accession #

O60344

GenBank Nucleotide #

NM_001100121.1

NCBI Official Full Name

endothelin-converting enzyme 2 isoform E

NCBI Official Synonym Full Names

endothelin converting enzyme 2

NCBI Official Symbol

ECE2

UniProt Protein Name

Endothelin-converting enzyme 2

Protein Family

Endothelin-converting enzyme

UniProt Gene Name

ECE2

UniProt Synonym Gene Names

KIAA0604; ECE-2

UniProt Entry Name

ECE2_HUMAN

NCBI Protein Information

endothelin-converting enzyme 2

NCBI Summary for ECE2

This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

UniProt Comments for ECE2

ECE2: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase, protein arginine, predicted; Protease; EC 3.4.24.71; Methyltransferase; Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: Golgi membrane; cytoplasmic vesicle membrane; integral to membrane

Molecular Function: methyltransferase activity; metal ion binding; metalloendopeptidase activity

Biological Process: methylation; cardioblast differentiation; cell-cell signaling; heart development; peptide hormone processing; brain development; proteolysis

Research Articles on ECE2

1. Te results of this study suggested taht genetic variations in MMEL1, ECE1, ECE2, AGER, PLG, PLAT, NR1H3, MMP3, LRP1, TTR, NR1H2, and MMP9 genes do not play major role among the Finnish AD patient cohort.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ECE2 antibody

Reference Product	PubMed Publications
EDNRB antibody	>2 publications with ECE2 and EDNRB
EDN2 antibody	>2 publications with ECE2 and EDN2
EDN1 antibody	>2 publications with ECE2 and EDN1
EDNRA antibody	>2 publications with ECE2 and EDNRA
EDN3 antibody	>1 publications with ECE2 and EDN3

Diseases associated with anti-ECE2 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>3 publications with ECE2 and Nervous System Diseases
Arterial Occlusive Diseases Antibodies	>1 publications with ECE2 and Arterial Occlusive Diseases
Inflammation Antibodies	>1 publications with ECE2 and Inflammation
Cardiovascular Diseases Antibodies	>1 publications with ECE2 and Cardiovascular Diseases

Organs/Tissues associated with anti-ECE2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>3 publications with ECE2 and Brain
Muscle Antibodies	>2 publications with ECE2 and Muscle
Liver Antibodies	>2 publications with ECE2 and Liver
Ovary Antibodies	>2 publications with ECE2 and Ovary
Embryonic Tissue Antibodies	>2 publications with ECE2 and Embryonic Tissue
Adrenal Gland Antibodies	>1 publications with ECE2 and Adrenal Gland
Lung Antibodies	>1 publications with ECE2 and Lung