NUPL1 Antibody – Mouse Monoclonal

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

NUPL1: a nuclear pore protein. Component of the p62 complex which includes NUP62, NUP54, and NUPL1. Interacts with NUTF2, and with KPNA2 and KPNB1 proteins when they are together, but not with KPNA2 alone. Located in the central region of the nuclear pore complex, biased towards thecytoplasmic side. Contains FG repeats. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleoporin; Nuclear import

Chromosomal Location of Human Ortholog: 13q12.13

Cellular Component: nuclear membrane; nuclear envelope; nuclear pore

Molecular Function: protein binding; nucleocytoplasmic transporter activity

Biological Process: mRNA transport; viral reproduction; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; nucleocytoplasmic transport; viral infectious cycle; glucose transport; protein transport; hexose transport; carbohydrate metabolic process; viral transcription; gene expression; mitotic cell cycle; transmembrane transport