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SERPINI1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6001983

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the… More details

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Product Overview

Online Datasheet in PDF
Product Name
SERPINI1, Polyclonal Antibody
Full Product Name
SERPINI1, NT (SERPINI1, PI12, Neuroserpin, Peptidase inhibitor 12, Serpin I1)
Product Gene Name
anti-SERPINI1 antibody
Product Synonym Names
Anti -SERPINI1, NT (SERPINI1, PI12, Neuroserpin, Peptidase inhibitor 12, Serpin I1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
46,427 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (167453432..167543357). Location: 3q26.1
OMIM
602445
3D Structure
ModBase 3D Structure for Q99574
Immunogen
SERPINI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of human SERPINI1.

Product Categories/Family for anti-SERPINI1 antibody

Antibodies; Abs to Protease Inhibitors
Applications Tested/Suitable for anti-SERPINI1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-SERPINI1 antibody
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Immunofluorescence: 1:10-50
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-SERPINI1 antibody

Western Blot analysis in HepG2 cell line lysates (35ug/lane) using MBS6001983. This demonstrates that MBS6001983 detected the SERPINI1 protein (arrow).
Rabbit Anti-SERPINI1 Polyclonal Antibody – Cat# MBS6001983

Western Blot (WB) of anti-SERPINI1 antibody

Western Blot analysis of lysate from SH-SY5Y cell line (35ug), using MBS6001983 (1:1000). A goat anti-rabbit IgG H&L (HRP) at 1:5000 was used as the secondary antibody.
Rabbit Anti-SERPINI1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6001983

Immunohistochemistry (IHC) of anti-SERPINI1 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue using MBS6001983 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6001983 for immunohistochemistry.
Rabbit Anti-SERPINI1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6001983

Immunofluorescence (IF) of anti-SERPINI1 antibody

Confocal immunofluorescent analysis of HepG2 cells using MBS6001983 followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-SERPINI1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6001983

Other Notes

Small volumes of anti-SERPINI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINI1 purchase

MBS6001983 is an antibody targeting SERPINI1. Also known as SERPINI1, NT (SERPINI1, PI12, Neuroserpin, Peptidase inhibitor 12, Serpin I1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINI1. It may not necessarily be applicable to this product.

NCBI GI #
17390079
NCBI GeneID
5274
NCBI Accession #
AAH18043.1
UniProt Primary Accession #
Q99574
UniProt Secondary Accession #
Q6AHZ4; A8K217; D3DNP1
UniProt Related Accession #
Q99574
NCBI Official Full Name
SERPINI1 protein
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade I (neuroserpin), member 1
NCBI Official Symbol
SERPINI1
NCBI Official Synonym Symbols
PI12; neuroserpin
UniProt Protein Name
Neuroserpin
UniProt Synonym Protein Names
Peptidase inhibitor 12; PI-12; Serpin I1
Protein Family
Neuroserpin
UniProt Gene Name
SERPINI1
UniProt Synonym Gene Names
PI12; PI-12
UniProt Entry Name
NEUS_HUMAN
NCBI Protein Information
neuroserpin; PI-12; serpin I1; peptidase inhibitor 12; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1

UniProt Comments for SERPINI1

SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: regulation of cell adhesion; central nervous system development; peripheral nervous system development

Disease: Encephalopathy, Familial, With Neuroserpin Inclusion Bodies
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Research Articles on SERPINI1

1. our study did not provide any evidence for an association between genetic variation at the SERPINI1 locus and ischemic stroke

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SERPINI1 antibody

 Reference Product  PubMed Publications
 PDCD10 antibody  >2 publications with SERPINI1 and PDCD10
 MYC antibody  >2 publications with SERPINI1 and MYC

Pathways associated with anti-SERPINI1 antibody

 Products by Pathway  Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram

Diseases associated with anti-SERPINI1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with SERPINI1 and Nervous System Diseases
 Mental Disorders Antibodies  >3 publications with SERPINI1 and Mental Disorders
 Liver Diseases Antibodies  >1 publications with SERPINI1 and Liver Diseases
 Schizophrenia Antibodies  >1 publications with SERPINI1 and Schizophrenia
 Cardiovascular Diseases Antibodies  >1 publications with SERPINI1 and Cardiovascular Diseases
 Familial encephalopathy with neuroserpin inclusion bodies Antibodies  >1 publications with SERPINI1 and Familial encephalopathy with neuroserpin inclusion bodies

Organs/Tissues associated with anti-SERPINI1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with SERPINI1 and Brain
 Liver Antibodies  >3 publications with SERPINI1 and Liver
 Stomach Antibodies  >1 publications with SERPINI1 and Stomach
 Muscle Antibodies  >1 publications with SERPINI1 and Muscle
 Embryonic Tissue Antibodies  >1 publications with SERPINI1 and Embryonic Tissue
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