PIK3C2B Antibody – Mouse Monoclonal

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

PIK3C2B: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. Belongs to the PI3/PI4-kinase family.

Protein type: Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; EC 2.7.1.154; Kinase, lipid

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: endocytic vesicle; endoplasmic reticulum; plasma membrane; cytosol; phosphoinositide 3-kinase complex; nucleus

Molecular Function: lipid kinase activity; protein binding; 1-phosphatidylinositol-3-kinase activity; phosphoinositide binding; phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding

Biological Process: phosphoinositide-mediated signaling; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; protein kinase B signaling cascade