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ELF3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6002206

ELF3 is a 41-43kD member of the ETS family of proteins. During uncomplicated (non-inflammatory) periods of cell differentiation, ELF3 is expressed exclusively by epithelial cells, repressing genes needed during early differentiation, and promoting genes… More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ELF3, Monoclonal Antibody
Full Product Name
ELF3 (E74-like Factor 3 (ets Domain Transcription Factor, Epithelial-specific), EPR-1, ERT, Epithelium-specific Ets Transcription Factor 1, ESE-1, Epithelial-restricted with Serine Box, ESX)
Product Gene Name
anti-ELF3 antibody
Product Synonym Names
Anti -ELF3 (E74-like Factor 3 (ets Domain Transcription Factor, Epithelial-specific), EPR-1, ERT, Epithelium-specific Ets Transcription Factor 1, ESE-1, Epithelial-restricted with Serine Box, ESX)
Immunogen Sequence
EGKKSKHAPR GTHLWEFIRD ILIHPELNEG LMKWENRHEG VFKFLRSEAV AQLWGQKKKN SNMTYEKLSR AMRYYYKREI LERVDGRRLV YKFGKNSSGW KEEEVLQSRN
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
1D8
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human ELF3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
41,454 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (201979647..201986316). Location: 1q32.2
OMIM
602191
3D Structure
ModBase 3D Structure for P78545
Immunogen
Partial recombinant corresponding to aa262-371 from human ELF3 (AAH03569) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-ELF3 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-ELF3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ELF3 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-ELF3 antibody

Western Blot detection against Immunogen (37.84kD).
Mouse Anti-ELF3 Monoclonal Antibody – Cat# MBS6002206

Western Blot (WB) of anti-ELF3 antibody

ELF3 monoclonal antibody, Western Blot analysis of ELF3 expression in A-431.
Mouse Anti-ELF3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6002206

Testing Data of anti-ELF3 antibody

Detection limit for recombinant GST tagged ELF3 is ~0.3ng/ml as a capture antibody.
Mouse Anti-ELF3 Monoclonal Antibody, Testing Data – Cat# MBS6002206

Other Notes

Small volumes of anti-ELF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ELF3 purchase

MBS6002206 is an antibody targeting ELF3. Also known as ELF3 (E74-like Factor 3 (ets Domain Transcription Factor, Epithelial-specific), EPR-1, ERT, Epithelium-specific Ets Transcription Factor 1, ESE-1, Epithelial-restricted with Serine Box, ESX). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ELF3. It may not necessarily be applicable to this product.

NCBI GI #
167235023
NCBI GeneID
1999
NCBI Accession #
NP_004424.3
UniProt Primary Accession #
P78545
UniProt Secondary Accession #
Q6IAP8; Q7RU03; Q7Z3X2; Q8NFG2; Q99718; B2R5Q6
UniProt Related Accession #
P78545
GenBank Nucleotide #
NM_004433.4
NCBI Official Full Name
ETS-related transcription factor Elf-3
NCBI Official Synonym Full Names
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
NCBI Official Symbol
ELF3
NCBI Official Synonym Symbols
ERT; ESX; EPR-1; ESE-1
UniProt Protein Name
ETS-related transcription factor Elf-3
UniProt Synonym Protein Names
E74-like factor 3; Epithelial-restricted with serine box; Epithelium-restricted Ets protein ESX; Epithelium-specific Ets transcription factor 1
Protein Family
ETS-related transcription factor
UniProt Gene Name
ELF3
UniProt Synonym Gene Names
ERT; ESX; JEN; ESE-1
UniProt Entry Name
ELF3_HUMAN
NCBI Protein Information
ETS-related transcription factor Elf-3; epithelial-restricted with serine box; epithelium-restricted Ets protein ESX; epithelium-specific Ets transcription factor 1; E74-like factor 3 (ets domain transcription factor); ets domain transcription factor, serine box (epithelial-specific); E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)

UniProt Comments for ELF3

ELF3: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Motility/polarity/chemotaxis; DNA-binding

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; transcription coactivator activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; mammary gland involution; epidermis development; blastocyst development; extracellular matrix organization and biogenesis; epithelial cell differentiation; multicellular organismal development; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; negative regulation of transcription, DNA-dependent
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Research Articles on ELF3

1. Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ELF3 antibody

 Reference Product  PubMed Publications
 ERBB2 antibody  >13 publications with ELF3 and ERBB2

Pathways associated with anti-ELF3 antibody

 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram

Diseases associated with anti-ELF3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >48 publications with ELF3 and Neoplasms
 Breast Neoplasms Antibodies  >16 publications with ELF3 and Breast Neoplasms
 Inflammation Antibodies  >14 publications with ELF3 and Inflammation
 Adenocarcinoma Antibodies  >8 publications with ELF3 and Adenocarcinoma
 Lung Neoplasms Antibodies  >6 publications with ELF3 and Lung Neoplasms
 Necrosis Antibodies  >5 publications with ELF3 and Necrosis
 Neoplasm Metastasis Antibodies  >4 publications with ELF3 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >4 publications with ELF3 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >2 publications with ELF3 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >2 publications with ELF3 and Cardiovascular Diseases

Organs/Tissues associated with anti-ELF3 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >11 publications with ELF3 and Embryonic Tissue
 Prostate Antibodies  >11 publications with ELF3 and Prostate
 Lung Antibodies  >11 publications with ELF3 and Lung
 Mammary Gland Antibodies  >10 publications with ELF3 and Mammary Gland
 Kidney Antibodies  >9 publications with ELF3 and Kidney
 Intestine Antibodies  >9 publications with ELF3 and Intestine
 Liver Antibodies  >6 publications with ELF3 and Liver
 Stomach Antibodies  >6 publications with ELF3 and Stomach
 Muscle Antibodies  >5 publications with ELF3 and Muscle
 Eye Antibodies  >5 publications with ELF3 and Eye
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