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PRPS2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6002247

PRPS2 is a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PRPS2, Polyclonal Antibody
Full Product Name
PRPS2, ID (PRPS2, Ribose-phosphate pyrophosphokinase 2, PPRibP, Phosphoribosyl pyrophosphate synthase II)
Product Gene Name
anti-PRPS2 antibody
Product Synonym Names
Anti -PRPS2, ID (PRPS2, Ribose-phosphate pyrophosphokinase 2, PPRibP, Phosphoribosyl pyrophosphate synthase II)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
34,769 Da
Chromosome Location
Chromosome: X; NC_000023.10 (12809474..12842346). Location: Xp22.2
OMIM
311860
3D Structure
ModBase 3D Structure for P11908
Immunogen
PRPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-106 amino acids from the Central region of human PRPS2.

Product Categories/Family for anti-PRPS2 antibody

Antibodies; Abs to Enzymes; Synthase
Applications Tested/Suitable for anti-PRPS2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PRPS2 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-PRPS2 antibody

PRPS2 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PRPS2 antibody detected the PRPS2 protein (arrow).
Rabbit Anti-PRPS2 Polyclonal Antibody – Cat# MBS6002247

Western Blot (WB) of anti-PRPS2 antibody

Western blot analysis of PRPS2 (arrow) using rabbit polyclonal PRPS2 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PRPS2 gene.
Rabbit Anti-PRPS2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6002247

Other Notes

Small volumes of anti-PRPS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRPS2 purchase

MBS6002247 is an antibody targeting PRPS2. Also known as PRPS2, ID (PRPS2, Ribose-phosphate pyrophosphokinase 2, PPRibP, Phosphoribosyl pyrophosphate synthase II). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRPS2. It may not necessarily be applicable to this product.

NCBI GI #
34192133
NCBI GeneID
5634
NCBI Accession #
AAH30019.2
UniProt Primary Accession #
P11908
UniProt Secondary Accession #
Q0VDH9; Q0VDI0; Q15245; Q2TAK7
UniProt Related Accession #
P11908
NCBI Official Full Name
PRPS2 protein, partial
NCBI Official Synonym Full Names
phosphoribosyl pyrophosphate synthetase 2
NCBI Official Symbol
PRPS2
NCBI Official Synonym Symbols
PRSII
UniProt Protein Name
Ribose-phosphate pyrophosphokinase 2
UniProt Synonym Protein Names
PPRibP; Phosphoribosyl pyrophosphate synthase II
UniProt Gene Name
PRPS2
UniProt Synonym Gene Names
PRS-II
UniProt Entry Name
PRPS2_HUMAN
NCBI Protein Information
ribose-phosphate pyrophosphokinase 2; PRS-II; PPRibP synthetase; ribose-phosphate diphosphokinase 2; phosphoribosyl pyrophosphate synthase II

NCBI Summary for PRPS2

This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
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UniProt Comments for PRPS2

PRPS2: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Belongs to the ribose-phosphate pyrophosphokinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, other; EC 2.7.6.1; Carbohydrate Metabolism - pentose phosphate pathway; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: Xp22.2

Molecular Function: ribose phosphate diphosphokinase activity; protein homodimerization activity; GDP binding; magnesium ion binding; kinase activity; carbohydrate binding; ADP binding; ATP binding; AMP binding

Biological Process: AMP biosynthetic process; organ regeneration; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; 5-phosphoribose 1-diphosphate biosynthetic process; phosphorylation
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Research Articles on PRPS2

1. Analysis of in vivo C-MYC interactions with TS, IMPDH2 and PRPS2 genes confirmed that they are direct C-MYC targets.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PRPS2 antibody

 Products by Pathway  Pathway Diagram
 5-Phosphoribose 1-diphosphate Biosynthesis Pathway antibodies  5-Phosphoribose 1-diphosphate Biosynthesis Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Nucleotide Metabolism Pathway antibodies  Nucleotide Metabolism Pathway Diagram
 PRPP Biosynthesis I Pathway antibodies  PRPP Biosynthesis I Pathway Diagram
 PRPP Biosynthesis, Ribose 5P => PRPP Pathway antibodies  PRPP Biosynthesis, Ribose 5P => PRPP Pathway Diagram

Diseases associated with anti-PRPS2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with PRPS2 and Neoplasms

Organs/Tissues associated with anti-PRPS2 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >2 publications with PRPS2 and Testis
 Pancreas Antibodies  >1 publications with PRPS2 and Pancreas
 Adipose Tissue Antibodies  >1 publications with PRPS2 and Adipose Tissue
 Placenta Antibodies  >1 publications with PRPS2 and Placenta
 Thymus Antibodies  >1 publications with PRPS2 and Thymus
 Liver Antibodies  >1 publications with PRPS2 and Liver
 Adrenal Gland Antibodies  >1 publications with PRPS2 and Adrenal Gland
 Lung Antibodies  >1 publications with PRPS2 and Lung
 Brain Antibodies  >1 publications with PRPS2 and Brain
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