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EXTL2 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6002556

Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
EXTL2, Polyclonal Antibody
Full Product Name
EXTL2 (Exostosin-like 2, Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, Alpha-GalNAcT EXTL2, EXT-related Protein 2, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, EXTR2)
Product Gene Name
anti-EXTL2 antibody
Product Synonym Names
Anti -EXTL2 (Exostosin-like 2, Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, Alpha-GalNAcT EXTL2, EXT-related Protein 2, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, EXTR2)
Immunogen Sequence
LLPSVKEDKM LMLRREIKSQ GKSTMDSFTL IMQTYNRTDL LLKLLNHYQA VPNLHKVIVV WNNIGEKAPD ELWNSLGPHP IPVIFKQQTA NRMRNRLQVF PELETNAVLM VDDDTLISTP DLVFAFSVWQ QFPDQIVGFV PRKHVSTSSG IYSYGSFEMQ APGSGNGDQY SMVLIGASFF NSKYLELFQR QPAAVHALID DTQNCDDIAM NFIIAKHIGK TSGIFVKPVN MDNLEKETNS GYSGMWHRAE HALQRSYCIN KLVNIYDSMP LRYSNITISQ FGFPYANYKR KI
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human EXTL2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
37,466 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (101337928..101361548, complement). Location: 1p21
OMIM
602411
3D Structure
ModBase 3D Structure for Q9UBQ6
Immunogen
Full length human EXTL2, aa39-330 (AAH36015).

Product Categories/Family for anti-EXTL2 antibody

Antibodies; Abs to Membrane Proteins
Applications Tested/Suitable for anti-EXTL2 antibody
Western Blot (WB)
Application Notes for anti-EXTL2 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-EXTL2 antibody

Western Blot analysis of EXTL2 expression in transfected 293T cell line by EXTL2 polyclonal antibody. Lane 1: EXTL2 transfected lysate (36.41kD). Lane 2: Non-transfected lysate.
Mouse Anti-EXTL2 Polyclonal Antibody – Cat# MBS6002556

Other Notes

Small volumes of anti-EXTL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EXTL2 purchase

MBS6002556 is an antibody targeting EXTL2. Also known as EXTL2 (Exostosin-like 2, Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, Alpha-GalNAcT EXTL2, EXT-related Protein 2, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, EXTR2). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for EXTL2. It may not necessarily be applicable to this product.

NCBI GI #
14149609
NCBI GeneID
2135
NCBI Accession #
NP_001430.1
UniProt Primary Accession #
Q9UBQ6
UniProt Secondary Accession #
B2R795; D3DT60
UniProt Related Accession #
Q9UBQ6
GenBank Nucleotide #
NM_001439.3
NCBI Official Full Name
exostosin-like 2 isoform 1
NCBI Official Synonym Full Names
exostosin-like glycosyltransferase 2
NCBI Official Symbol
EXTL2
NCBI Official Synonym Symbols
EXTR2
UniProt Protein Name
Exostosin-like 2
UniProt Synonym Protein Names
Alpha-1,4-N-acetylhexosaminyltransferase EXTL2; Alpha-GalNAcT EXTL2; EXT-related protein 2; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Protein Family
Exostosin
UniProt Gene Name
EXTL2
UniProt Synonym Gene Names
EXTR2
UniProt Entry Name
EXTL2_HUMAN
NCBI Protein Information
exostosin-like 2; alpha-GalNAcT EXTL2; EXT-related protein 2; processed exostosin-like 2; exostoses (multiple)-like 2; alpha-1,4-N-acetylhexosaminyltransferase EXTL2; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

UniProt Comments for EXTL2

EXTL2: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Belongs to the glycosyltransferase 47 family.

Protein type: Membrane protein, integral; EC 2.4.1.223; Glycan Metabolism - heparan sulfate biosynthesis; Transferase

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: metal ion binding; alpha-1,4-N-acetylgalactosaminyltransferase activity; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

Biological Process: glycosaminoglycan biosynthetic process; N-acetylglucosamine metabolic process; heparan sulfate proteoglycan biosynthetic process; UDP-N-acetylgalactosamine metabolic process
Show more

Research Articles on EXTL2

1. EXTL2 functions to suppress GAG biosynthesis that is enhanced by a xylose kinase and the EXTL2-dependent mechanism that regulates GAG biosynthesis might be a "quality control system" for proteoglycans

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EXTL2 antibody

 Reference Product  PubMed Publications
 EXT2 antibody  >14 publications with EXTL2 and EXT2
 EXT1 antibody  >14 publications with EXTL2 and EXT1

Pathways associated with anti-EXTL2 antibody

 Products by Pathway  Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
 Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway antibodies  Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway Diagram
 Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway antibodies  Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway Diagram
 Heparan Sulfate Biosynthesis Pathway antibodies  Heparan Sulfate Biosynthesis Pathway Diagram
 Heparan Sulfate Biosynthesis Pathway antibodies  Heparan Sulfate Biosynthesis Pathway Diagram
 Heparan Sulfate Biosynthesis (late Stages) Pathway antibodies  Heparan Sulfate Biosynthesis (late Stages) Pathway Diagram
 Heparan Sulfate Biosynthesis (late Stages) Pathway antibodies  Heparan Sulfate Biosynthesis (late Stages) Pathway Diagram

Diseases associated with anti-EXTL2 antibody

 Disease Name  Pubmed Publications
 Musculoskeletal Diseases Antibodies  >10 publications with EXTL2 and Musculoskeletal Diseases
 Neoplasms Antibodies  >9 publications with EXTL2 and Neoplasms
 Fibrosis Antibodies  >1 publications with EXTL2 and Fibrosis
 Liver Diseases Antibodies  >1 publications with EXTL2 and Liver Diseases
 Drug-Induced Liver Injury Antibodies  >1 publications with EXTL2 and Drug-Induced Liver Injury

Organs/Tissues associated with anti-EXTL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >9 publications with EXTL2 and Bone
 Embryonic Tissue Antibodies  >3 publications with EXTL2 and Embryonic Tissue
 Muscle Antibodies  >2 publications with EXTL2 and Muscle
 Liver Antibodies  >2 publications with EXTL2 and Liver
 Kidney Antibodies  >2 publications with EXTL2 and Kidney
 Heart Antibodies  >1 publications with EXTL2 and Heart
 Parathyroid Antibodies  >1 publications with EXTL2 and Parathyroid
 Vascular Antibodies  >1 publications with EXTL2 and Vascular
 Eye Antibodies  >1 publications with EXTL2 and Eye
 Brain Antibodies  >1 publications with EXTL2 and Brain
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