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CPLX1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6003317

CPLX1 encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CPLX1, Polyclonal Antibody
Full Product Name
CPLX1, ID (CPLX1, Complexin-1, Complexin I, Synaphin-2)
Product Gene Name
Product Synonym Names
Anti -CPLX1, ID (CPLX1, Complexin-1, Complexin I, Synaphin-2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
15,122 Da
Chromosome Location
Chromosome: 5; NC_000071.6 (108518554..108550027, complement). Location: 5 F; 5
3D Structure
ModBase 3D Structure for P63040
Immunogen
CPLX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39~69 amino acids from the Central region of human CPLX1.

Product Categories/Family for anti-Cplx1 antibody

Applications Tested/Suitable for anti-Cplx1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Cplx1 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100

Western Blot (WB) of anti-Cplx1 antibody

Western blot analysis of CPLX1 Antibody (Center) in mouse brain tissue lysates (35ug/lane). CPLX1 (arrow) was detected using the purified Pab.
Rabbit Anti-CPLX1 Polyclonal Antibody – Cat# MBS6003317

Immunohistochemistry (IHC) of anti-Cplx1 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with CPLX1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CPLX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6003317

Other Notes

Small volumes of anti-Cplx1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cplx1 purchase

MBS6003317 is an antibody targeting Cplx1. Also known as CPLX1, ID (CPLX1, Complexin-1, Complexin I, Synaphin-2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Cplx1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
complexin-1
NCBI Official Synonym Full Names
complexin 1
NCBI Official Symbol
Cplx1
NCBI Official Synonym Symbols
921-S
UniProt Protein Name
Complexin-1
UniProt Synonym Protein Names
921-S; Complexin I; CPX I; Synaphin-2
UniProt Gene Name
Cplx1
UniProt Synonym Gene Names
CPX I
UniProt Entry Name
CPLX1_MOUSE
NCBI Protein Information
complexin-1; CPX I; synaphin-2; complexin I

UniProt Comments for Cplx1

CPLX1: Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Belongs to the complexin/synaphin family.

Protein type: Vesicle

Cellular Component: SNARE complex; protein complex; cell soma; cell; cytoplasm; dendrite; terminal button; synapse

Molecular Function: SNARE binding; syntaxin binding; syntaxin-1 binding; neurotransmitter transporter activity

Biological Process: synaptic vesicle exocytosis; exocytosis; insulin secretion; transport; neurotransmitter transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-Cplx1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with Cplx1 and Brain
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