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A4GALT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6004862

The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found… More details

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Product Overview

Online Datasheet in PDF
Product Name
A4GALT, Polyclonal Antibody
Full Product Name
A4GALT, NT (A4GALT, A14GALT, A4GALT1, Lactosylceramide 4-alpha-galactosyltransferase, Alpha-1,4-N-acetylglucosaminyltransferase, Alpha-1,4-galactosyltransferase, Alpha4Gal-T1, CD77 synthase, Globotriaosylceramide synthase, P1/Pk synthase, UDP-galactose:be
Product Gene Name
anti-A4GALT antibody
Product Synonym Names
Anti -A4GALT, NT (A4GALT, A14GALT, A4GALT1, Lactosylceramide 4-alpha-galactosyltransferase, Alpha-1,4-N-acetylglucosaminyltransferase, Alpha-1,4-galactosyltransferase, Alpha4Gal-T1, CD77 synthase, Globotriaosylceramide synthase, P1/Pk synthase, UDP-galactose:be
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
40,499 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (43088123..43117307, complement). Location: 22q13.2
OMIM
111400
3D Structure
ModBase 3D Structure for Q9NPC4
Immunogen
A4GALT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human A4GALT.

Product Categories/Family for anti-A4GALT antibody

Antibodies; Abs to Enzymes; Glycosyltransferase
Applications Tested/Suitable for anti-A4GALT antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-A4GALT antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-A4GALT antibody

A4GALT Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the A4GALT antibody detected the A4GALT protein (arrow).
Rabbit Anti-A4GALT Polyclonal Antibody – Cat# MBS6004862

Other Notes

Small volumes of anti-A4GALT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for A4GALT purchase

MBS6004862 is an antibody targeting A4GALT. Also known as A4GALT, NT (A4GALT, A14GALT, A4GALT1, Lactosylceramide 4-alpha-galactosyltransferase, Alpha-1,4-N-acetylglucosaminyltransferase, Alpha-1,4-galactosyltransferase, Alpha4Gal-T1, CD77 synthase, Globotriaosylceramide synthase, P1/Pk synthase, UDP-galactose:be. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for A4GALT. It may not necessarily be applicable to this product.

NCBI GI #
33115183
NCBI GeneID
53947
NCBI Accession #
AAH55286.1
UniProt Primary Accession #
Q9NPC4
UniProt Secondary Accession #
Q9P1X5; B2R7C4
UniProt Related Accession #
Q9NPC4
NCBI Official Full Name
A4GALT protein
NCBI Official Synonym Full Names
alpha 1,4-galactosyltransferase
NCBI Official Symbol
A4GALT
NCBI Official Synonym Symbols
P1; PK; Gb3S; P(k); P1PK; A14GALT; A4GALT1
UniProt Protein Name
Lactosylceramide 4-alpha-galactosyltransferase
UniProt Synonym Protein Names
Alpha-1,4-N-acetylglucosaminyltransferase; Alpha-1,4-galactosyltransferase; Alpha4Gal-T1; CD77 synthase; Globotriaosylceramide synthase; Gb3 synthase; P1/Pk synthase; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
Protein Family
Lactosylceramide 4-alpha-galactosyltransferase
UniProt Gene Name
A4GALT
UniProt Synonym Gene Names
A14GALT; A4GALT1; Gb3 synthase
UniProt Entry Name
A4GAT_HUMAN
NCBI Protein Information
lactosylceramide 4-alpha-galactosyltransferase; GB3 synthase; alpha4Gal-T1; CD77 synthase; P1/Pk synthase; P(k) antigen synthase; P blood group (P one antigen); globotriaosylceramide synthase; alpha-1,4-N-acetylglucosaminyltransferase; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase

UniProt Comments for A4GALT

A4GALT: Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins. Belongs to the glycosyltransferase 32 family.

Protein type: Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Transferase; Membrane protein, integral; EC 2.4.1.228

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: membrane; integral to Golgi membrane

Molecular Function: toxin binding; galactosyltransferase activity; lactosylceramide 4-alpha-galactosyltransferase activity

Biological Process: globoside biosynthetic process; glycosphingolipid biosynthetic process; plasma membrane organization and biogenesis; protein amino acid glycosylation

Disease: Blood Group, P1pk System
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Research Articles on A4GALT

1. Results suggest that the C631G mutation alters the acceptor specificity of Gb3/CD77 synthase, rendering it able to catalyze synthesis of the Gal(alpha1-4)Gal and Gal(alpha1-4)GalNAc moieties.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-A4GALT antibody

 Reference Product  PubMed Publications
 ABO antibody  >1 publications with A4GALT and ABO
 B3GALNT1 antibody  >1 publications with A4GALT and B3GALNT1

Pathways associated with anti-A4GALT antibody

 Products by Pathway  Pathway Diagram
 Glycosphingolipid Biosynthesis - Globo Series Pathway antibodies  Glycosphingolipid Biosynthesis - Globo Series Pathway Diagram
 Glycosphingolipid Biosynthesis - Globo Series Pathway antibodies  Glycosphingolipid Biosynthesis - Globo Series Pathway Diagram
 Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway antibodies  Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway Diagram
 Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway antibodies  Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway Diagram

Diseases associated with anti-A4GALT antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >2 publications with A4GALT and Immune System Diseases
 Lymphoma Antibodies  >1 publications with A4GALT and Lymphoma
 Carcinoma Antibodies  >1 publications with A4GALT and Carcinoma
 Immunologic Deficiency Syndromes Antibodies  >1 publications with A4GALT and Immunologic Deficiency Syndromes
 Inflammation Antibodies  >1 publications with A4GALT and Inflammation

Organs/Tissues associated with anti-A4GALT antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with A4GALT and Bone
 Ovary Antibodies  >1 publications with A4GALT and Ovary
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